Case of localized scleroderma successfully treated with bath psoralen and ultraviolet A therapy


Ryoji Tsuboi, M.D., Ph.D., 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. Email:


The patient was a 12-year-old girl with linear scleroderma distributed on the right abdomen, dorsal aspect of the right thigh, lower leg and foot. The initial regimen of oral prednisolone and methotrexate, or i.v. methylprednisolone failed in the treatment of the scleroderma. Then bath psoralen and ultraviolet A therapy (bath-PUVA) therapy of 0.2 J–4.0 J/cm2 daily to total doses 62.8 J/cm2 combined with oral prednisolone was started. After bath-PUVA therapy, regression of the skin sclerosis was observed, the possible mobile range of the right ankle was increased and histological examination confirmed improvement of the sclerosis. The successful results of bath-PUVA therapy in this case suggest its utility for localized scleroderma.