Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low-dose warfarin
Version of Record online: 24 JAN 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Special Issue: Systemic Sclerosis (pages 1-84)
Volume 37, Issue 1, pages 98–101, January 2010
How to Cite
OSADA, S.-I., KIMURA, Y. and KAWANA, S. (2010), Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low-dose warfarin. The Journal of Dermatology, 37: 98–101. doi: 10.1111/j.1346-8138.2009.00754.x
- Issue online: 24 JAN 2010
- Version of Record online: 24 JAN 2010
- Received 25 March 2009; accepted 16 September 2009.
- livedo racemosa;
- livedoid vasculopathy;
- peripheral neuropathy;
We report herein a case of a 28-year-old woman with persistent livedo racemosa and recurrent ulcerations on the lower extremities. The clinical presentation, together with histopathological findings of vascular occlusion without overt vasculitis in the dermis, led to the diagnosis of livedoid vasculopathy. The patient experienced recurrence of ulcerations and developed peripheral neuropathy affecting the distal extremities during the course of treatment with sarpogrelate hydrochloride. The skin lesions and neurological symptoms improved dramatically after adding low-dose warfarin potassium to the treatment regimen. This case suggests that administration of low-dose warfarin is an effective therapy of choice for patients with livedoid vasculopathy.