Animal model of systemic sclerosis
Article first published online: 24 JAN 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Special Issue: Systemic Sclerosis (pages 1-84)
Volume 37, Issue 1, pages 26–41, January 2010
How to Cite
YAMAMOTO, T. (2010), Animal model of systemic sclerosis. The Journal of Dermatology, 37: 26–41. doi: 10.1111/j.1346-8138.2009.00764.x
- Issue published online: 24 JAN 2010
- Article first published online: 24 JAN 2010
- Received 15 October 2009; accepted 25 October 2009.
- mouse model;
Scleroderma is a fibrotic condition characterized by immunological abnormalities, vascular injury and increased accumulation of extracellular matrix proteins in the skin. Although the etiology of scleroderma has not yet been fully elucidated, a growing body of evidence suggests that extracellular matrix overproduction by activated fibroblasts results from a complex interaction among endothelial cells, lymphocytes, macrophages and fibroblasts, through a number of mediators, such as cytokines, chemokines and growth factors. For a better understanding of the pathophysiology of scleroderma, animal models are important tools. These models reproduce several histological as well as biochemical aspects of human scleroderma, and we can learn a lot through animal studies. On the other hand, it must be emphasized that studying animal models cannot answer all the problems of human scleroderma. In this review, I introduce current insights into the pathogenesis and also recent updates of therapeutic approaches using several animal models of SSc, and discuss their contribution to our understanding of the pathogenesis of, and treatments for, human scleroderma.