Efficacy of a far erythemogenic dose of narrow-band ultraviolet B phototherapy in chronic plaque-type psoriasis
Article first published online: 3 FEB 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Volume 37, Issue 2, pages 140–145, February 2010
How to Cite
AKARAPHANTH, R., KITTIPAVARA, Y., VORAVUTINON, N., WACHIRATARAPADORN, U. and GRITIYARANGSAN, P. (2010), Efficacy of a far erythemogenic dose of narrow-band ultraviolet B phototherapy in chronic plaque-type psoriasis. The Journal of Dermatology, 37: 140–145. doi: 10.1111/j.1346-8138.2009.00776.x
- Issue published online: 3 FEB 2010
- Article first published online: 3 FEB 2010
- Received 27 April 2009; accepted 14 September 2009.
- chronic plaque-type psoriasis;
- Dermatology Life Quality Index score;
- far erythemogenic dose narrow-band ultraviolet B;
- Psoriasis Area and Severity Index score
The aim of the present study was to examine the effect of far erythemogenic dose of narrow-band ultraviolet B (NB-UVB; starting dose at 35% minimal erythematous dose [MED]) on clinical response by measuring the severity, extent of disease and the changes in quality of life. Fifty patients with chronic plaque-type psoriasis were enrolled. Therapy was held for 3 days a week. The severity of the disease was assessed based on the Psoriasis Area and Severity Index (PASI) score and Dermatology Life Quality Index (DLQI) scores. The percentage improvement of PASI at 30 sessions was 68.99%. The improvement in DLQI scores at 30 sessions was 79.67%. Pearson correlation coefficients showed that PASI scores were not correlated with DLQI scores at the beginning of treatment (P = 0.330, r = 0.14), but after the 30th session of NB-UVB therapy improvements in quality of life were correlated (P < 0.05, r = 0.399). Therefore, far erythemogenic dose of NB-UVB is considered to be effective treatment for plaque-type psoriasis in our patients. However, we cannot confirm that it is safer than higher MED starting dose in term of cumulative UV irradiation.