Bullous pemphigoid as a dermadrome associated with spindle cell carcinoma of the gallbladder
Article first published online: 26 FEB 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Special Issue: Blistering Diseases (pages 193-239)
Volume 37, Issue 3, pages 251–254, March 2010
How to Cite
UMEKOJI, A., TSURUTA, D., INOUE, T., NISHIMORI, T. and ISHII, M. (2010), Bullous pemphigoid as a dermadrome associated with spindle cell carcinoma of the gallbladder. The Journal of Dermatology, 37: 251–254. doi: 10.1111/j.1346-8138.2009.00795.x
- Issue published online: 26 FEB 2010
- Article first published online: 26 FEB 2010
- Received 11 March 2009; accepted 16 September 2009.
- bullous pemphigoid;
- gallbladder carcinoma;
- spindle cell carcinoma
Skin disorders that appear in association with internal malignancies are called dermadromes. Bullous pemphigoid (BP), which is a major autoimmune disease of the skin, is considered to be a dermadrome, although there have been conflicting reports. We report a case of BP that preceded the diagnosis of an internal malignancy. Although we could not detect any malignancies on chest, abdominal or pelvic computer tomography on the first hospital admission, intensive screening on the third admission revealed a gallbladder malignancy. Laparoscopic cholecystectomy was performed. Histopathology showed a spindle cell carcinoma of the gallbladder. To the best of our knowledge, this is the first report of a spindle cell carcinoma of the gallbladder in a patient with BP.