Acquired reactive perforating collagenosis: Current status
Article first published online: 30 JUN 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Volume 37, Issue 7, pages 585–592, July 2010
How to Cite
KARPOUZIS, A., GIATROMANOLAKI, A., SIVRIDIS, E. and KOUSKOUKIS, C. (2010), Acquired reactive perforating collagenosis: Current status. The Journal of Dermatology, 37: 585–592. doi: 10.1111/j.1346-8138.2010.00918.x
- Issue published online: 30 JUN 2010
- Article first published online: 30 JUN 2010
- Received 10 February 2008; accepted 1 April 2010.
- acquired reactive perforating collagenosis;
- perforating dermatoses;
- transepidermal penetration;
- transepidermal perforating dermal collagen
Acquired reactive perforating collagenosis is a unique perforating dermatosis, characterized clinically by umbilicated hyperkeratotic papules or nodules and histologically by a focal hyperkeratosis in direct contact with transepidermal perforating dermal collagen. Several inflammatory or malignant systemic diseases may coexist with acquired reactive perforating collagenosis. The possible biochemical or immunological mechanisms of the systemic diseases, potentially responsible for the development and appearance of acquired reactive perforating collagenosis, are still under investigation. Several topical treatments, ultraviolet B phototherapy and allopurinol p.o. administration may be effective.