Acquired reactive perforating collagenosis: Current status


Anthony Karpouzis, M.D., Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, 92 Karaoli and Dimitriou Street, 68100 Alexandroupolis, Greece. Email:


Acquired reactive perforating collagenosis is a unique perforating dermatosis, characterized clinically by umbilicated hyperkeratotic papules or nodules and histologically by a focal hyperkeratosis in direct contact with transepidermal perforating dermal collagen. Several inflammatory or malignant systemic diseases may coexist with acquired reactive perforating collagenosis. The possible biochemical or immunological mechanisms of the systemic diseases, potentially responsible for the development and appearance of acquired reactive perforating collagenosis, are still under investigation. Several topical treatments, ultraviolet B phototherapy and allopurinol p.o. administration may be effective.