Langerhans cell histiocytosis treated with narrow-band ultraviolet B
Article first published online: 17 AUG 2010
© 2010 Japanese Dermatological Association
The Journal of Dermatology
Volume 38, Issue 2, pages 151–154, February 2011
How to Cite
AIHARA, M., HASEGAWA, T., OKUYAMA, Y., HIRUMA, M. and IKEDA, S. (2011), Langerhans cell histiocytosis treated with narrow-band ultraviolet B. The Journal of Dermatology, 38: 151–154. doi: 10.1111/j.1346-8138.2010.00959.x
- Issue published online: 27 JAN 2011
- Article first published online: 17 AUG 2010
- Received 15 October 2009; accepted 17 March 2010.
- Langerhans cell histiocytosis;
- narrow-band ultraviolet B;
- psoralen and ultraviolet A therapy
A 58-year-old man had widespread multiple erythemas that had been untreated for 20 years. The cutaneous lesions increased in size for a year. Histopathological examination revealed increased number of large, dysplastic, histiocytic cells in the dermis; most of these cells tested positive for Langelin, CD1a and S-100 staining. The patient was diagnosed with Langerhans cell histiocytosis (LCH) and treated with narrow-band ultraviolet B (NB-UVB) radiation. The erythema improved after treatment, but the tumor remained. Therefore, the tumor was surgically excised. NB-UVB therapy might be effective for the treatment of superficial lesions, but not tumoral lesions of LCH.