Oral acanthosis nigricans in chronic hepatitis B with a 21-year follow up
Version of Record online: 4 OCT 2011
© 2011 Japanese Dermatological Association
The Journal of Dermatology
Volume 38, Issue 12, pages 1172–1176, December 2011
How to Cite
CHRYSOMALI, E., PIPERI, E. and SKLAVOUNOU-ANDRIKOPOULOU, A. (2011), Oral acanthosis nigricans in chronic hepatitis B with a 21-year follow up. The Journal of Dermatology, 38: 1172–1176. doi: 10.1111/j.1346-8138.2011.01252.x
- Issue online: 22 NOV 2011
- Version of Record online: 4 OCT 2011
- Received 13 April 2010; accepted 7 February 2011.
- acanthosis nigricans;
- chronic hepatitis B;
Acanthosis nigricans is a rare mucocutaneous disorder of unknown etiology that manifests as hyperpigmented velvety plaques, most often on intertriginous areas such as the neck and axillae as well as on mucosal sites such as the oral cavity. The disorder presents either as a paraneoplastic manifestation of an underlying malignancy, especially gastrointestinal adenocarcinomas or in association with obesity, administration of drugs or endocrinopathies, most commonly insulin-resistant diabetes mellitus. In the present article, a case of acanthosis nigricans with oral and cutaneous manifestations in a male patient with chronic hepatitis B infection is described. To the best of our knowledge, this is the first case of benign oral acanthosis nigricans associated with chronic hepatitis B.