Nosocomial outbreak of multidrug-resistant USA300 methicillin-resistant Staphylococcus aureus causing severe furuncles and carbuncles in Japan
Article first published online: 18 OCT 2011
© 2011 Japanese Dermatological Association
The Journal of Dermatology
Volume 38, Issue 12, pages 1167–1171, December 2011
How to Cite
MINE, Y., HIGUCHI, W., TAIRA, K., NAKASONE, I., TATEYAMA, M., YAMAMOTO, T., UEZATO, H. and TAKAHASHI, K. (2011), Nosocomial outbreak of multidrug-resistant USA300 methicillin-resistant Staphylococcus aureus causing severe furuncles and carbuncles in Japan. The Journal of Dermatology, 38: 1167–1171. doi: 10.1111/j.1346-8138.2011.01284.x
- Issue published online: 22 NOV 2011
- Article first published online: 18 OCT 2011
- Received 19 December 2010; accepted 23 March 2011.
- community-associated methicillin-resistant Staphylococcus aureus;
- nosocomial outbreak;
- pulsed-field gel electrophoresis;
- USA300 clone
USA300 methicillin-resistant Staphylococcus aureus (MRSA) has been attracting worldwide attention as a cause of community-associated MRSA (CA-MRSA) infections in the 21st century. Nosocomial outbreaks of CA-MRSA clones have been progressively more reported in Europe and the USA, but only one very recent report from Kyoto found in Japan. In February 2008, a severe MRSA infection occurred in one immunocompromised patient and three healthy medical staff members at the Department of Dermatology, Graduate School of Medicine, University of the Ryukyus. The epidemiological and clinical pattern of the infection prompted us to characterize the molecular features of the MRSA strain involved. The causative MRSA strain belonged to the multi-locus sequence type 8, staphylococcal cassette chromosome mec (SCCmec) type IVa, spa1 (alternatively t008), agr1 and coagulase type III, and carried the Panton–Valentine leukocidin (PVL) gene and the arginine catabolic mobile element. Pulsed-field gel electrophoresis analysis showed that the MRSA responsible for the outbreak was the USA300 clone. All of the isolated USA300 clones had multiple resistance against six non-β-lactam antimicrobial drugs. We report here the first nosocomial outbreak of multidrug-resistant USA300 MRSA infections in Japan. This report shows that the USA300 clone can manifest severe skin infections such as furuncles and carbuncles even in healthy persons, which require drainage and i.v. treatment, and suggests that the clone can spread in hospital settings worldwide.