Three siblings with systemic lupus erythematosus
Version of Record online: 2 DEC 2011
© 2011 Japanese Dermatological Association
The Journal of Dermatology
Volume 39, Issue 2, pages 164–167, February 2012
How to Cite
SHU, E., ICHIKI, Y., MORIYA, C., IWATA, H., KITAJIMA, Y. and SEISHIMA, M. (2012), Three siblings with systemic lupus erythematosus. The Journal of Dermatology, 39: 164–167. doi: 10.1111/j.1346-8138.2011.01333.x
- Issue online: 24 JAN 2012
- Version of Record online: 2 DEC 2011
- Received 18 October 2010; accepted 27 April 2011.
- human leukocyte antigen A2;
- human leukocyte antigen DR4;
- systemic lupus erythematosus
We present the cases of three siblings with systemic lupus erythematosus (SLE). The diagnosis was made when the sisters were of age 21, 25 and 28 years. They shared some clinical features, including typical facial rash, photosensitivity and Raynaud’s phenomenon, and tested positive for antinuclear antibodies. However, their symptoms and clinical courses varied. Human leukocyte antigen (HLA) typing revealed that DR4 and A2 were present in all three sisters, while HLA type A11, B35 and B54 were each found in two of the three sisters. The two elder sisters developed lupus glomerulonephritis 8 and 11 years after the onset of SLE. It is suggested that there are genes responsible for the onset of the disease and also unknown regulatory genes other than HLA result in different phenotypes.