Quantitative study of stratum corneum ceramides contents in patients with sensitive skin
Article first published online: 31 OCT 2011
© 2011 Japanese Dermatological Association
The Journal of Dermatology
Special Issue: Special Issue: Psoriasis (pages 211-289)
Volume 39, Issue 3, pages 295–300, March 2012
How to Cite
CHO, H. J., CHUNG, B. Y., LEE, H. B., KIM, H. O., PARK, C. W. and LEE, C. H. (2012), Quantitative study of stratum corneum ceramides contents in patients with sensitive skin. The Journal of Dermatology, 39: 295–300. doi: 10.1111/j.1346-8138.2011.01406.x
- Issue published online: 21 FEB 2012
- Article first published online: 31 OCT 2011
- Received 20 December 2010; accepted 25 July 2011.
- lactic acid sting test;
- sensitive skin;
- stratum corneum ceramides
People with sensitive skin (SS) are those who state their skin is more sensitive than that of average persons. The stratum corneum is responsible for maintaining skin barrier function. Ceramides, major constituents of stratum corneum lipids, have been shown to predominantly contribute to the role. It has been suggested that barrier function in SS is decreased. However, we could find very few reports about stratum corneum ceramides in SS. This study was done to find out differences in stratum corneum ceramides between SS and non-SS groups. Fifty individuals (20 with SS and 30 with non-SS) were recruited. Lactic acid sting test (LAST) was performed on the left cheek. On six sites including the right cheek, arm, thigh, leg, back and palm, transepidermal water loss (TEWL) and erythema index (EI) were measured. On the above six sites, stratum corneum sheets were obtained by stripping with cyanoacrylate resin and stratum corneum lipids were extracted, then, analyzed by high-performance liquid chromatography electrospray ionization mass spectrometry. LAST scores were higher in the SS group, but not statistically significant. There were no differences in TEWL and EI values between the two groups. The mean value of the quantity of stratum corneum ceramides on the face was significantly lower in the SS group. On other sites, mean values were also lower in the SS group, but not statistically significant. The quantity of ceramides was significantly decreased in the face of the SS group compared to that of the non-SS group. These results suggest that the decrease in stratum corneum ceramides on facial skin could be related to SS development.