Clinical follow-up study of adult-onset Still’s disease
Article first published online: 27 JUN 2012
© 2012 Japanese Dermatological Association
The Journal of Dermatology
Volume 39, Issue 11, pages 898–901, November 2012
How to Cite
NAGAI, Y., HASEGAWA, M., OKADA, E., HATTORI, T., TAGO, O. and ISHIKAWA, O. (2012), Clinical follow-up study of adult-onset Still’s disease. The Journal of Dermatology, 39: 898–901. doi: 10.1111/j.1346-8138.2012.01600.x
- Issue published online: 29 OCT 2012
- Article first published online: 27 JUN 2012
- Received 2 April 2012; accepted 1 May 2012.
- adult-onset Still’s disease;
- atypical skin rash;
- prognostic factor;
Eighteen patients with adult-onset Still’s disease have been followed up for 3–22 years in our department. Initial manifestations were fever with skin rash in 14 patients, fever, skin rash and sore throat in two, skin rash in one and arthralgia in one. During the follow-up period, typical skin rash was seen in all patients, of them five patients (29%) revealed atypical skin rash simultaneously. Atypical rash included persistent erythema with pigmentation in two, persistent plaques and papules with linear erythema in two and edema of the eyelids mimicking dermatomyositis in one. Persistent papules and plaques revealed histologically characteristic features, such as dyskeratotic keratinocyte and liquefaction degeneration as well as a sparse superficial dermal infiltrate containing scattered neutrophils. In patients of chronic articular type and polycyclic systemic type, atypical skin rash, lymphadenopathy and hyperferritinemia were noted to be significantly higher than those of monocyclic type. These factors might be prognostic factors of adult-onset Still’s disease in our study.