Conflict of interest: none.
Two cases of livedo vasculopathy with non-criteria antiphospholipid antibodies
Article first published online: 14 SEP 2012
© 2012 Japanese Dermatological Association
The Journal of Dermatology
Volume 39, Issue 12, pages 1026–1030, December 2012
How to Cite
Hasegawa, M., Fujimoto, M., Orito, H., Matsushita, T., Hamaguchi, Y. and Takehara, K. (2012), Two cases of livedo vasculopathy with non-criteria antiphospholipid antibodies. The Journal of Dermatology, 39: 1026–1030. doi: 10.1111/j.1346-8138.2012.01664.x
- Issue published online: 26 NOV 2012
- Article first published online: 14 SEP 2012
- Manuscript Accepted: 25 JUL 2012
- Manuscript Received: 30 MAY 2012
- antiphospholipid antibody;
- skin thrombosis
Livedo vasculopathy is characterized by reticular distribution of purpuric macules and papules of the lower legs, caused by intraluminal thrombosis of small vessels. Antiphospholipid antibodies are detected in a subset of these patients. We treated two cases (a 34-year-old man and a 46-year-old woman) with livedo vasculopathy. In both cases, thrombosis was seen only in the skin. The presence of immunoglobulin (Ig)G or IgM anticardiolipin antibody (Ab), IgG or IgM anti-β2-glycoprotein I Ab, or lupus anticoagulant are necessary for criteria-based diagnosis of antiphospholipid syndrome. However, our patients were negative for these Ab, and instead had either IgG antiphosphatidylethanolamine Ab or IgA anticardiolipin Ab. These Ab are suggestive of antiphospholipid syndrome but are not considered “criteria” Ab. This report demonstrates the existence of antiphosphatidylethanolamine Ab or IgA anticardiolipin Ab in patients with livedo vasculopathy. However, the frequency and significance of these Ab in livedo vasculopathy should be confirmed in larger longitudinal studies.