• 1
    Blake, P.A., Weaver, R.E., and Hollis, D.G. 1980. Diseases of humans (other than cholerae) caused by vibrios. Annu. Rev. Microbiol. 34: 341367.
  • 2
    Carruthers, M.M. 1975. Cytotoxicity of Vibrio parahaemolyticus in HeLa cell culture. J. Infect. Dis. 132: 555560.
  • 3
    Chowdhury, N.R., Chakraborty, S., Ramamurthy, T., Nishibuchi, M., Yamasaki, S., Takeda, Y., and Nair, G.B. 2000. Molecular evidence of clonal Vibrio parahaemolyticus pandemic strains. Emerg. Infect. Dis. 6: 631636.
  • 4
    Daniels, N.A., MacKinnon, L., Bishop, R., Altekruse, S., Ray, B., Hammond, R.M., Thompson, S., Wilson, S., Bean, N.H., Griffin, P.M., and Slutsker, L. 2000. Vibrio parahaemolyticus infections in the United States, 1973–1998. J. Infect. Dis. 181: 16611666.
  • 5
    Goshima, K., Honda, T., Hirata, M., Kikuchi, K., Takeda, Y., and Miwatani, T. 1977. Stopping of the spontaneous beating of mouse and rat myocardial cells in vitro by a toxin from Vibrio parahaemolyticus. J. Mol. Cell. Cardiol. 9: 191213.
  • 6
    Honda, T., and Iida, T. 1993. The pathogenicity of Vibrio parahaemolyticus and the role of the thermostable direct haemolysin and related haemolysin. Rev. Med. Microbiol. 4: 106113.
  • 7
    Honda, T., Goshima, K., Takeda, Y., Sugino, Y., and Miwatani, T. 1976. Demonstration of the cardiotoxicity of the thermosatble direct hemolysin (lethal toxin) produced by Vibrio parahaemolyticus. Infect. Immun. 13: 163171.
  • 8
    Honda, T., Ni, Y., Hata, A., Yoh, M., and Miwatani, T. 1990. Properties of a hemolysin related to the thermostable direct hemolysin produced by a Kanagawa negative, clinical isolate of Vibrio parahaemolyticus. Can. J. Microbiol. 36: 395399.
  • 9
    Honda, T., Ni, Y., and Miwatani, T. 1988. Purification and characterization of a hemolysin produced by a clinical isolate of Kanagawa phenomenon-negative Vibrio parahaemolyticus and related to the thermostable direct hemolysin. Infect. Immun. 56: 961965.
  • 10
    Honda, T., Takeda, Y., Miwatani, T., Kato, K., and Nimura, Y. 1976. Clinical features of patients suffering from food poisoning due to Vibrio parahaemolyticus, especially on changes in electrocardiograms. J. Jpn. Assoc. Infect. Dis. 50: 216223.
  • 11
    Iida, T., and Yamamoto, K. 1990. Cloning and expression of two genes encoding highly homologous hemolysins from a Kanagawa-positive Vibrio parahaemolyticus T4750 strain. Gene 93: 915.
  • 12
    Kodama, T., Akeda, Y., Kono, G., Takahashi, A., Imura, K., Iida, T., and Honda, T. 2002. The EspB protein of enterohaemorrhagic Escherichia coli interacts directly with α-catenin. Cell. Microbiol. 4: 213222.
  • 13
    Makino, K., Oshima, K., Kurokawa, K., Yokoyama, K., et al. 2003. Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae. Lancet 361: 743749.
  • 14
    Miller, V.L., and Mekalanos, J.J. 1988. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J. Bacteriol. 170: 25752583.
  • 15
    Miyamoto, Y., Kato, T., Obara, Y., Akiyama, S., Takizawa, K., and Yamai, S. 1969. In vitro hemolytic characteristic of Vibrio parahaemolyticus: its close correlation with human pathogenicity. J. Bacteriol. 100: 11471149.
  • 16
    Miyamoto, Y., Obara, Y., Nikkawa, T., Yamai, S., Kato, T., Yamada, Y., and Ohashi, M. 1980. Simplified purification and biophysicochemical characteristics of Kanagawa phenomenon-associated hemolysin of Vibrio parahaemolyticus. Infect. Immun. 28: 567576.
  • 17
    Naim, R., Yanagihara, I., Iida, T., and Honda, T. 2001. Vibrio parahaemolyticus thermostable direct hemolysin can induce an apoptotic cell death in Rat-1 cells from inside and outside of the cells. FEMS Microbiol. Lett. 195: 237244.
  • 18
    Naim, R., Iida, T., Takahashi, A., and Honda, T. 2001. Monodansylcadaverine inhibits cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin on cultured rat embryonic fibroblast cells. FEMS Microbiol. Lett. 196: 99105.
  • 19
    Nasu, H., Iida, T., Sugahara, T., Yamaichi, Y., Park, K.S., Yokoyama, K., Makino, K., Shinagawa, H., and Honda, T. 2000. A filamentous phage associated with recent pandemic Vibrio parahaemolyticus O3:K6 strains. J. Clin. Microbiol. 38: 21562161.
  • 20
    Nishibuchi, M., Fasano, A., Russell, R.G., and Kaper, J.B. 1992. Enterotoxigenicity of Vibrio parahaemolyticus with and without genes encoding thermostable direct hemolysin. Infect. Immun. 60: 35393545.
  • 21
    Nishibuchi, M., and Kaper, J.B. 1995. Thermostable direct hemolysin gene of Vibrio parahaemolyticus: a virulence gene acquired by a marine bacterium. Infect. Immun. 63: 20932099.
  • 22
    Nishibuchi, M., Kumagai, K., and Kaper, J.B. 1991. Contribution of the tdh 1 gene of Kanagawa phenomenon-positive Vibrio parahaemolyticus to production of extracellular thermostable direct hemolysin. Microb. Pathog. 11: 453460.
  • 23
    Raimondi, F., Kao, J.P.Y., Fiorentini, C., Fabbri, A., Donelli, G., Gasparini, N., Rubino, A., and Fasano, A. 2000. Enterotoxicity and cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin in in vitro systems. Infect. Immun. 68: 31803185.
  • 24
    Sakazaki, R., Tamura, K., Kato, T., Obara, Y., Yamai, S., and Hobo, K. 1968. Studies on the enteropathogenic, facultatively halophilic bacteria. Vibrio parahaemolyticus. III. Enteropathogenicity. Jpn. J. Med. Sci. Biol. 21: 325331.
  • 25
    Sakurai, J., Honda, T., Jinguji, Y., Arita, M., and Miwatani, T. 1976. Cytotoxic effect of the thermostable direct hemolysin produced by Vibrio parahaemolyticus on FL cells. Infect. Immun. 13: 876883.
  • 26
    Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
  • 27
    Shirai, H., Ito, H., Hirayama, T., Nakabayashi, Y., Kumagai, K., Takeda, Y., and Nishibuchi, M. 1990. Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis. Infect. Immun. 58: 35683573.
  • 28
    Smith, D.M., Kazi, A., Smith, L., Long, T.E., Heldreth, B., Turos, E., and Dou, Q.P. 2002. A novel β-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage. Mol. Pharmacol. 61: 13481358.
  • 29
    Tang, G.Q., Iida, T., Yamamoto, K., and Honda, T. 1995. Ca2+-independent cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin (TDH) on intestine 407, a cell line derived from human embryonic intestine. FEMS Microbiol. Lett. 134: 233238.
  • 30
    Tang, G.Q., Iida, T., Yamamoto, K., and Honda, T. 1997. Analysis of functional domains of Vibrio parahaemolyticus thermostable direct hemolysin using monoclonal antibodies. FEMS Microbiol. Lett. 150: 289296.
  • 31
    Tang, G.Q., Iida, T., Inoue, H., Yutsudo, M., Yamamoto, K., and Honda, T. 1997. A mutant cell line resistant to Vibrio parahaemolyticus thermostable direct hemolysin (TDH): its potential in identification of putative receptor for TDH. Biochim. Biophys. Acta 1360: 277282.
  • 32
    Twedt, R.M., Peeler, J.T., and Spaulding, P.L. 1980. Effective ileal loop dose of Kanagawa-positive Vibrio parahaemolyticus. Appl. Environ. Microbiol. 40: 10121016.
  • 33
    Xu, M., Yamamoto, K., and Honda, T. 1994. Construction and characterization of an isogenic mutant of Vibrio parahaemolyticus having a deletion in the thermostable direct hemolysin-related hemolysin gene (trh). J. Bacteriol. 176: 47574760.