Roles of the interactions between Env and Gag proteins in the HIV-1 replication cycle
Article first published online: 3 JUN 2008
© 2008 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 52, Issue 5, pages 287–295, May 2008
How to Cite
Murakami, T. (2008), Roles of the interactions between Env and Gag proteins in the HIV-1 replication cycle. Microbiology and Immunology, 52: 287–295. doi: 10.1111/j.1348-0421.2008.00008.x
- Issue published online: 3 JUN 2008
- Article first published online: 3 JUN 2008
- Received 26 November 2007; accepted 15 December 2007.
- Env glycoprotein;
- Env incorporation;
- membrane microdomains;
- human immunodeficiency virus type 1
The Env and Gag proteins of HIV-1 are the two major structural proteins of this retrovirus. The interactions between Env and Gag proteins and their regulation in HIV-1 are required for several steps of the replication cycle, involving not only virus assembly, specifically Env incorporation, but also entry steps after virus maturation. A large number of host factors and certain membrane microdomains appear to engage both in transport/trafficking of Env and/or Gag proteins, and in the interactions of these two proteins. The present review briefly summarizes our current knowledge regarding the roles of the interactions between Env and Gag proteins in the virus replication cycle.