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- SYNTHESIS AND TRANSPORT/TRAFFICKING OF ENV
- SYNTHESIS AND TRAFFICKING OF GAG
- ROLE OF ENV-GAG INTERACTIONS IN ENV INCORPORATION INTO VIRIONS AND VIRUS RELEASE
- ROLE OF MEMBRANE MICRODOMAINS IN ENV-GAG INTERACTIONS AND HIV-1 ASSEMBLY
- ROLE OF ENV-GAG INTERACTIONS IN HIV-1 ENTRY
The Env and Gag proteins of HIV-1 are the two major structural proteins of this retrovirus. The interactions between Env and Gag proteins and their regulation in HIV-1 are required for several steps of the replication cycle, involving not only virus assembly, specifically Env incorporation, but also entry steps after virus maturation. A large number of host factors and certain membrane microdomains appear to engage both in transport/trafficking of Env and/or Gag proteins, and in the interactions of these two proteins. The present review briefly summarizes our current knowledge regarding the roles of the interactions between Env and Gag proteins in the virus replication cycle.