Incorporation of β-amyloid protein through the bovine ileal epithelium before and after weaning: Model for orally transmitted amyloidoses
Article first published online: 21 JUL 2008
© 2008 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 52, Issue 8, pages 429–434, August 2008
How to Cite
Ano, Y., Nakayama, H., Sakai, Y., Sakudo, A., Endo, M., Ebisu, S., Li, J., Uetsuka, K., Manabe, N. and Onodera, T. (2008), Incorporation of β-amyloid protein through the bovine ileal epithelium before and after weaning: Model for orally transmitted amyloidoses. Microbiology and Immunology, 52: 429–434. doi: 10.1111/j.1348-0421.2008.00054.x
- Issue published online: 21 JUL 2008
- Article first published online: 21 JUL 2008
- Received 3 March 2008; accepted 14 April 2008.
- β-amyloid protein;
- bovine spongiform encephalopathy;
- suckling period;
To determine the mechanism of bovine intestinal incorporation of the pathogen, and the pathogenesis of prion protein in the early stage, cows suckling and weaning were orally given a fusion protein of Aβ-EGFP. Aβ-EGFP was incorporated through the villous columnar epithelial cells and accumulated in crypt patches in the ileum of suckling cows. The sites of the uptake and accumulation of Aβ-EGFP are very close to the peripheral nervous system; however, such uptake of Aβ-EGFP was not observed in 6-month-old post-weaning cows. The present study, therefore, suggests that the weaning period is very important for the risk of transmission.