Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors
Article first published online: 28 APR 2009
© 2009 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 53, Issue 8, pages 468–474, August 2009
How to Cite
Horiuchi, Y., Tominaga, M., Ichikawa, M., Yamashita, M., Jikumaru, Y., Nariai, Y., Nakajima, Y., Kuwabara, M. and Yukawa, M. (2009), Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors. Microbiology and Immunology, 53: 468–474. doi: 10.1111/j.1348-0421.2009.00144.x
- Issue published online: 22 JUL 2009
- Article first published online: 28 APR 2009
- Received 28 December 2008; revised 23 March 2009; accepted 26 March 2009.
- metastatic tumor;
It is well known that lymphocytes from patients with advanced-stage cancer have impaired immune responsiveness and that type1 T lymphocyte subsets in tumor bearing hosts are suppressed. Treg have been reported to comprise a subgroup which inhibits T cell mediated immune responses. In the present study, the percentage of Treg, Th1 and Tc1 in the peripheral blood of tumor bearing dogs with or without metastases was evaluated. The percentages of Th1 and Tc1 in dogs with metastatic tumor were significantly less, and that of Treg was significantly greater, than those of dogs without metastatic tumor. The percentage of Treg showed an inverse correlation with that of Th1 and Tc1 in tumor bearing dogs. It was concluded that an increase in Treg in the peripheral blood of dogs with metastatic tumor may induce suppression of tumor surveillance by the Type1 immune response and lead to metastasis of tumor.