These authors contributed equally to this work.
Intraspecies transmission of L-type-like bovine spongiform encephalopathy detected in Japan
Article first published online: 21 AUG 2009
© 2009 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 53, Issue 12, pages 704–707, December 2009
How to Cite
Fukuda, S., Iwamaru, Y., Imamura, M., Masujin, K., Shimizu, Y., Matsuura, Y., Shu, Y., Kurachi, M., Kasai, K., Murayama, Y., Onoe, S., Hagiwara, K., Sata, T., Mohri, S., Yokoyama, T. and Okada, H. (2009), Intraspecies transmission of L-type-like bovine spongiform encephalopathy detected in Japan. Microbiology and Immunology, 53: 704–707. doi: 10.1111/j.1348-0421.2009.00169.x
- Issue published online: 30 NOV 2009
- Article first published online: 21 AUG 2009
- Received 7 May 2009; revised 2 August 2009; accepted 4 August 2009.
- atypical bovine spongiform encephalopathy;
It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L-type-like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.