Plasma lipoproteins are important components of the immune system
Version of Record online: 5 APR 2010
© 2010 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 54, Issue 4, pages 246–253, April 2010
How to Cite
Han, R. (2010), Plasma lipoproteins are important components of the immune system. Microbiology and Immunology, 54: 246–253. doi: 10.1111/j.1348-0421.2009.00203.x
- Issue online: 5 APR 2010
- Version of Record online: 5 APR 2010
- Received 5 October 2009; revised 14 December 2009; accepted 17 December 2009.
- innate immunity;
- plasma lipoprotein
Plasma lipoproteins (VLDL, LDL, Lp[a] and HDL) function primarily in lipid transport among tissues and organs. However, cumulative evidence suggests that lipoproteins may also prevent bacterial, viral and parasitic infections and are therefore a component of innate immunity. Lipoproteins can also detoxify lipopolysaccharide and lipoteichoic acid. Infections can induce oxidation of LDL, and oxLDL in turn plays important anti-infective roles and protects against endotoxin-induced tissue damage. There is also evidence that apo(a) is protective against pathogens. Taken together, the evidence suggests that it might be valuable to introduce the concept that plasma lipoproteins belong in the realm of host immune response.