• 1
    Wasley A., Alter M.J. (2000) Epidemiology of hepatitis C: geographic differences and temporal trends. Semin Liver Disease 20: 116.
  • 2
    Manns M.P., Mchutchison J.G., Gordon S.C., Rustgi V.K., Shiffman M., Reindollar R., Goodman, Z.D., Koury K., Ling M., Albrecht J.K. (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358: 95865.
  • 3
    Lindenbach B.D., Evans M.J., Syder A.J., Wolk B., Tellinghuisen T.L., Liu C.C., Maruyama T., Hynes R.O., Burton D.R., Mckeating J.A., Rice C.M. (2005) Complete replication of hepatitis C virus in cell culture. Science 309: 6236.
  • 4
    Wakita T., Pietschmann T., Kato T., Date T., Miyamoto M., Zhao Z., Murthy K., Habermann A., Krausslich H.G., Mizokami M., Bartenschlager R., Liang T.J. (2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11: 7916.
  • 5
    Zhong J., Gastaminza P., Cheng G., Kapadia S., Kato T., Burton D.R., Wieland S.F., Uprichard S.L., Wakita T., Chisari F.V. (2005) Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A 102: 92949.
  • 6
    Kanda T., Basu A., Steele R., Wakita T., Ryerse J.S., Ray R., Ray R.B. (2006) Generation of infectious hepatitis C virus in immortalized human hepatocytes. J Virol 80: 46339.
  • 7
    Yi M., Villanueva R.A., Thomas D.L., Wakita T., Lemon S.M. (2006) Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc Natl Acad Sci U S A 103: 23105.
  • 8
    Okamoto T., Nishimura Y., Ichimura T., Suzuki K., Miyamura T., Suzuki T., Moriishi K., Matsuura Y. (2006) Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J 25: 501525.
  • 9
    Taguwa S., Okamoto T., Abe T., Mori Y., Suzuki T., Moriishi K., Matsuura Y. (2008) Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication. J Virol 82: 263141.
  • 10
    Hamamoto I., Nishimura Y., Okamoto T., Aizaki H., Liu M., Mori Y., Abe T., Suzuki T., Lai M.M., Miyamura T., Moriishi K., Matsuura Y. (2005) Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. J Virol 79: 1347382.
  • 11
    Meylan E., Curran J., Hofmann K., Moradpour D., Binder M., Bartenschlager R., Tschopp J. (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 116772.
  • 12
    Li X.D., Sun L., Seth R.B., Pineda G., Chen Z.J. (2005) Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A 102: 1771722.
  • 13
    Steinkuhler C., Urbani A., Tomei L., Biasiol G., Sardana M., Bianchi E., Pessi A., De Francesco R. (1996) Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol 70: 6694700.
  • 14
    Lin C., Pragai B.M., Grakoui A., Xu J., Rice C.M. (1994) Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol 68: 814757.
  • 15
    Lei Y., Moore C.B., Liesman R.M., O’connor B.P., Bergstralh D.T., Chen Z.J., Pickles R.J., Ting J.P. (2009) MAVS-mediated apoptosis and its inhibition by viral proteins. PloS One 4: e5466.
  • 16
    Koutsoudakis G., Kaul A., Steinmann E., Kallis S., Lohmann V., Pietschmann T., Bartenschlager R. (2006) Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol 80: 530820.
  • 17
    Moradpour D., Evans M.J., Gosert R., Yuan Z., Blum H.E., Goff S.P., Lindenbach B.D., Rice C.M. (2004) Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J Virol 78: 74009.
  • 18
    Wolk B., Buchele B., Moradpour D., Rice C.M. (2008) A dynamic view of hepatitis C virus replication complexes. J Virol 82: 1051931.
  • 19
    Pan K.L., Lee J.C., Sung H.W., Chang T.Y., Hsu J.T. (2009) Development of NS3/4A protease-based reporter assay suitable for efficiently assessing hepatitis C virus infection. Antimicrob Agents Chemother 53: 482534.
  • 20
    Iro M., Witteveldt J., Angus A.G., Woerz I., Kaul A., Bartenschlager R., Patel A.H. (2009) A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication. Antiviral Res 83: 14855.
  • 21
    Breiman A., Vitour D., Vilasco M., Ottone C., Molina S., Pichard L., Fournier C., Delgrange D., Charneau P., Duverlie G., Wychowski C., Maurel P., Meurs E.F. (2006) A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells. J Gen Virol 87: 358798.
  • 22
    Mori Y., Yamashita T., Tanaka Y., Tsuda Y., Abe T., Moriishi K., Matsuura Y. (2007) Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells. J Virol 81: 847787.
  • 23
    Ho S.N., Hunt H.D., Horton R.M., Pullen J.K. Pease L.R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77: 519.
  • 24
    Matsuo E., Tani H., Lim C., Komoda Y., Okamoto T., Miyamoto H., Moriishi K., Yagi S., Patel A.H., Miyamura T., Matsuura Y. (2006) Characterization of HCV-like particles produced in a human hepatoma cell line by a recombinant baculovirus. Biochem Biophys Res Commun 340: 2008.
  • 25
    Masaki T., Suzuki R., Matsuda M., Miyamura T., Wakita T., and Suzuki T. (2006) Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription, abstr. 209. P. 59. In Abstracts of the 13th International Meeting on Hepatitis C Virus and Related Viruses, Nola Miles-Clark, Cairns, Australia.
  • 26
    Okamoto T., Omori H., Kaname Y., Abe T., Nishimura Y., Suzuki T., Miyamura T., Yoshimori T., Moriishi K., Matsuura Y. (2008) A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication. J Virol 82: 34809.
  • 27
    Lohmann V., Korner F., Koch J., Herian U., Theilmann L. Bartenschlager R. (1999) Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285: 1103.
  • 28
    Shirakura M., Murakami K., Ichimura T., Suzuki R., Shimoji T., Fukuda K., Abe K., Sato S., Fukasawa M., Yamakawa Y., Nishijima M., Moriishi K., Matsuura Y., Wakita T., Suzuki T., Howley P.M., Miyamura T., Shoji I. (2007) E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J Virol 81: 117485.
  • 29
    Tani H., Komoda Y., Matsuo E., Suzuki K., Hamamoto I., Yamashita T., Moriishi K., Fujiyama K., Kanto T., Hayashi N., Owsianka A., Patel A.H., Whitt M.A., Matsuura Y. (2007) Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins. J Virol 81: 860112.
  • 30
    Akrigg A., Wilkinson G.W., Angliss S., Greenaway P.J. (1991) HIV-1 indicator cell lines. AIDS 5: 1538.
  • 31
    Xiao, H., Lis, J.T., Jeang, K.T. (1997) Promoter activity of Tat at steps subsequent to TATA-binding protein recruitment. Mol Cell Biol 17: 6898905.
  • 32
    Horie C., Suzuki H., Sakaguchi M., Mihara K. (2002) Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane. Mol Biol Cell 13: 161525.
  • 33
    Brady J., Kashanchi F. (2005) Tat gets the “green” light on transcription initiation. Retrovirology 2: 69.
  • 34
    Cormier E.G., Tsamis F., Kajumo F., Durso R.J., Gardner J.P., Dragic T. (2004) CD81 is an entry coreceptor for hepatitis C virus. Proc Natl Acad Sci USA 101: 72704.
  • 35
    Aizaki H., Morikawa K., Fukasawa M., Hara H., Inoue Y., Tani H., Saito K., Nishijima M., Hanada K., Matsuura Y., Lai M.M., Miyamura T., Wakita T., Suzuki T. (2008) Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection. J Virol 82: 571524.
  • 36
    Guo J.T., Bichko V.V., Seeger C. (2001) Effect of alpha interferon on the hepatitis C virus replicon. J Virol 75: 851623.
  • 37
    Zhang J., Duan X., Zhang H., Deng Z., Zhou Z., Wen N., Smith A.J., Zhao W., Jin Y. (2006) Isolation of neural crest-derived stem cells from rat embryonic mandibular processes. Biol Cell 98: 56775.
  • 38
    Barnett S.C., Alexander C.L., Iwashita Y., Gilson J.M., Crowther J., Clark L., Dunn L.T., Papanastassiou V., Kennedy P.G., Franklin R.J. (2000) Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. Brain 123: 15818.
  • 39
    Brune M.E., Katwala S.P., Milicic I., Witte D.G., Kerwin J.F. Jr., Meyer M.D., Hancock A.A., Williams M. (2002) Effect of fiduxosin, an antagonist selective for alpha(1A)- and alpha(1D)-adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther 300: 48794.
  • 40
    Santi C.M., Cayabyab F.S., Sutton K.G., Mcrory J.E., Mezeyova J., Hamming K.S., Parker D., Stea A., Snutch T.P. (2002) Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci 22: 396403.
  • 41
    Tobiume M., Takahoko M., Tatsumi M., Matsuda M. (2001) Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity. J Virol Methods 97: 1518.
  • 42
    Kimpton J., Emerman M. (1992) Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene. J Virol 66: 22329.
  • 43
    Loo Y.M., Owen D.M., Li K., Erickson A.K., Johnson C.L., Fish P.M., Carney D.S., Wang T., Ishida H., Yoneyama M., Fujita T., Saito T., Lee W.M., Hagedorn C.H., Lau D.T., Weinman S.A., Lemon S.M., Gale M. Jr. (2006) Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A 103: 60016.
  • 44
    Tai A.W., Benita Y., Peng L.F., Kim S.S., Sakamoto N., Xavier R.J., Chung R.T. (2009) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 5: 298307.
  • 45
    So H.S., Kim H.J., Lee J.H., Lee J.H., Park S.Y., Park C., Kim Y.H., Kim J.K., Lee K.M., Kim K.S., Chung S.Y., Jang W.C., Moon S.K., Chung H.T., Park R.K. (2006) Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin. Cell Death Differentiation 13: 176375.
  • 46
    Zhu Z., Wilson A.T., Mathahs M.M., Wen F., Brown K.E., Luxon B.A., Schmidt W.N. (2008) Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury. Hepatology 48: 14309.
  • 47
    Aly H.H., Qi Y., Atsuzawa K., Usuda N., Takada Y., Mizokami M., Shimotohno K., Hijikata M. (2009) Strain-dependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus. Hepatology 50: 68996.
  • 48
    Valli M.B., Serafino A., Crema A., Bertolini L., Manzin A., Lanzilli G., Bosman C., Iacovacci S., Giunta S., Ponzetto A., Clementi M., Carloni G. (2006) Transmission in vitro of hepatitis C virus from persistently infected human B-cells to hepatoma cells by cell-to-cell contact. J Med Virol 78: 192201.
  • 49
    Witteveldt J., Evans M.J., Bitzegeio J., Koutsoudakis G., Owsianka A.M., Angus A.G., Keck Z.Y., Foung S.K., Pietschmann T., Rice C.M., Patel A.H. (2009) CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. J Gen Virol 90: 4858.
  • 50
    Timpe J.M., Stamataki Z., Jennings A., Hu K., Farquhar M.J., Harris H.J., Schwarz A., Desombere I., Roels G.L., Balfe P., Mckeating J.A. (2008) Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology 47: 1724.
  • 51
    Stamataki Z., Shannon-Lowe C., Shaw J., Mutimer D., Rickinson A.B., Gordon J., Adams D.H., Balfe P., Mckeating J.A. (2009) Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells. Blood 113: 58593.