ORIGINAL ARTICLE

A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease

  1. Mikiya Fujieda1,
  2. Rie Karasawa2,
  3. Hisashi Takasugi1,
  4. Masaki Yamamoto1,
  5. Koichi Kataoka4,5,
  6. Kazuo Yudoh6,
  7. Tomohiro Kato6,
  8. Shoichi Ozaki3,
  9. Hiroshi Wakiguchi1

Article first published online: 13 FEB 2012

DOI: 10.1111/j.1348-0421.2011.00393.x

Issue

Microbiology and Immunology

Microbiology and Immunology

Volume 56, Issue 1, pages 56–61, January 2012

Additional Information

How to Cite

Fujieda, M., Karasawa, R., Takasugi, H., Yamamoto, M., Kataoka, K., Yudoh, K., Kato, T., Ozaki, S. and Wakiguchi, H. (2012), A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease. Microbiology and Immunology, 56: 56–61. doi: 10.1111/j.1348-0421.2011.00393.x

Author Information

  1. 1

    Department of Pediatrics, Kochi Medical School, Kochi University, Kochi

  2. 2

    Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki

  3. 3

    Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki

  4. 4

    Department of Pediatrics, Kochi Health Science Center, Kochi

  5. 5

    Pediatric Operating Suite and Intensive Care Unit, Jichi Children's Center Tochigi, Tochigi

  6. 6

    Department of Biochemistry, St. Marianna University School of Medicine, Kawasaki, Japan

*Mikiya Fujieda, Department of Pediatrics, Kochi Medical School, Kochi University Kohasu, Oko-cho, Nankoku, Kochi 783–8505, Japan. Tel: +81 88 880 2355; Fax: +81 880 2356; email: fujiedam@kochi-u.ac.jp

Publication History

  1. Issue published online: 13 FEB 2012
  2. Article first published online: 13 FEB 2012
  3. Accepted manuscript online: 17 OCT 2011 05:38AM EST
  4. Received 21 July 2011; revised 28 September 2011; accepted 30 September 2011.

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Keywords:

  • Kawasaki disease;
  • oxidative stress;
  • peroxiredoxin;
  • 8-isoprostaglandin F2α

ABSTRACT

Antibodies to the anti-oxidative peroxiredoxin (Prx) enzymes occur in both systemic autoimmune disease and vasculitis in adulthood. Because increased oxidative stress induces vasculitis in Kawasaki disease (KD), autoimmunity to Prxs in patients with KD was investigated. The presence of antibodies to Prx 1, 2 and 4 was analyzed by ELISA and Western blot. Of 30 patients with KD, 13 (43.3%) possessed antibodies to Prx 2, whereas these antibodies were present in only 1 of 10 patients (10.0%) with sepsis (4 with purulent meningitis and 6 with septicemia). In contrast, antibodies to Prx 1 and 4 were not detected in either group. There was no significant correlation among the titers of the three antibodies. Clinical parameters were compared between anti-Prx 2-positive and -negative patients. The presence of anti-Prx 2 antibodies correlated with a longer period of fever and poor response to high-dose γ-globulin therapy in patients with KD. Anti-Prx 2-positive patients had significantly greater excretion of urinary 8-isoprostaglandin than did anti-Prx 2-negative patients. These results provide the first evidence for an antibody to Prx 2 in patients with KD. They also suggest that this antibody might serve as a marker of disease severity and be involved in the pathophysiology of vasculitis in some patients with KD.

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