In vitro models for analysis of the hepatitis C virus life cycle
Article first published online: 13 FEB 2012
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 56, Issue 1, pages 1–9, January 2012
How to Cite
Aly, H. H., Shimotohno, K., Hijikata, M. and Seya, T. (2012), In vitro models for analysis of the hepatitis C virus life cycle. Microbiology and Immunology, 56: 1–9. doi: 10.1111/j.1348-0421.2011.00403.x
- Issue published online: 13 FEB 2012
- Article first published online: 13 FEB 2012
- Accepted manuscript online: 7 DEC 2011 04:36AM EST
- Received 8 September 2011; revised 23 October 2011; accepted 3 November 2011.
- hepatitis C virus;
- HuH-7 cell;
- knockout mice;
- type I interferon
Chronic hepatitis C virus (HCV) infection affects approximately 170 million people worldwide. HCV infection is a major global health problem as it can be complicated with liver cirrhosis and hepatocellular carcinoma. So far, there is no vaccine available and the non-specific, interferon (IFN)-based treatments now in use have significant side-effects and are frequently ineffective, as only approximately 50% of treated patients with genotypes 1 and 4 demonstrate HCV clearance. The lack of suitable in vitro and in vivo models for the analysis of HCV infection has hampered elucidation of the HCV life cycle and the development of both protective and therapeutic strategies against HCV infection. The present review focuses on the progress made towards the establishment of such models.