Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms
Article first published online: 13 MAR 2012
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd
Microbiology and Immunology
Volume 56, Issue 2, pages 123–127, February 2012
How to Cite
Harada, K., Arima, S., Niina, A., Kataoka, Y. and Takahashi, T. (2012), Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms. Microbiology and Immunology, 56: 123–127. doi: 10.1111/j.1348-0421.2011.00416.x
- Issue published online: 13 MAR 2012
- Article first published online: 13 MAR 2012
- Accepted manuscript online: 20 DEC 2011 10:30PM EST
- Received 7 September 2011; revised 28 November 2011; accepted 7 December 2011.
- antimicrobial resistance;
- companion animals;
- Pseudomonas aeruginosa.
Seventy-three Pseudomonas aeruginosa isolates were collected from dogs and cats in Japan to investigate antimicrobial susceptibility and resistance mechanisms to anti-pseudomonal agents. Resistance rates against orbifloxacin, enrofloxacin, ciprofloxacin, cefotaxime, aztreonam and gentamicin were 34.2, 31.5, 20.5, 17.8, 12.3 and 4.1%, respectively. The degree of resistance to cefotaxime, orbifloxacin, and enrofloxacin was greatly affected by efflux pump inhibitors, indicating overexpression of efflux pump contributes to these resistances. Notably, orbifloxacin and enrofloxacin resistance was observed even in isolates without mutations in the target sites. This is the first report on cephalosporin- and fluoroquinolone-resistant isolates of P. aeruginosa from Japanese companion animals.