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ORIGINAL ARTICLE
Cross-reactive antibody response to the pandemic A (H1N1) 2009 influenza virus induced by vaccination with a seasonal trivalent influenza vaccine: a longitudinal study of three influenza seasons in Japan
Article first published online: 29 NOV 2012
DOI: 10.1111/j.1348-0421.2012.00511.x
© 2012 The Societies and Wiley Publishing Asia Pty Ltd
Additional Information
How to Cite
Uno, S., Kimachi, K., Matsuo, F., Miyazaki, K., Oohama, A., Kei, J., Nishimura, T., Odoh, K. and Kino, Y. (2012), Cross-reactive antibody response to the pandemic A (H1N1) 2009 influenza virus induced by vaccination with a seasonal trivalent influenza vaccine: a longitudinal study of three influenza seasons in Japan. Microbiology and Immunology, 56: 810–816. doi: 10.1111/j.1348-0421.2012.00511.x
Publication History
- Issue published online: 29 NOV 2012
- Article first published online: 29 NOV 2012
- Accepted manuscript online: 26 SEP 2012 04:17AM EST
- Received 30 January 2012; revised 1 September 2012; accepted 12 September 2012.
- Abstract
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Keywords:
- cross-reactive antibody response;
- longitudinal study;
- pandemic H1N1 2009 vaccine;
- seasonal influenza vaccine
ABSTRACT
The cross-reactivity of antibody to the swine-origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 2007–2008 season but not in the other two seasons. The proportion of individuals with HI antibody titers ≥ 1:40 did not change significantly from year to year. These results indicate that cross-reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.