SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    ) Liotta , L. A. , Rao , C. V. Barsky , S. H. Tumor invasion and the extracellular matrix . Lab. Invest , 49 , 636649 ( 1983 ).
  • 2
    ) Strauli , P. and Haemmerli , G. The role of cell motility in invasion . Cancer Metastasis Rev. , 3 , 127141 ( 1984 ).
  • 3
    ) McCarthy , J. B. , Basara , M. L. , Palm , S. L. , Sas , D. F. and Furcht , L. T. The role of cell adhesion proteins—laminin and fibronectin—in the movement of malignant and metastatic cells . Cancer Metastasis Rev. , 4 , 125152 ( 1985 ).
  • 4
    ) Nicolson , G. L. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression . Cancer Res. , 47 , 14731487 ( 1987 ).
  • 5
    ) McCarthy , J. B. and Furcht , L. T. Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro . J. Cell Biol. , 98 , 14741480 ( 1984 ).
  • 6
    ) Verani , J. Chemotaxis of metastatic tumor cells . Cancer Metastasis Rev. , 1 , 1728 ( 1982 ).
  • 7
    ) Fidler , I. J. Gersten , D. M. and Hart , I. R. The biology of cancer invasion and metastases . Adv. Cancer Res. , 28 , 149250 ( 1978 ).
  • 8
    ) Umezawa , H. , Aoyagi , T. , Suda , H. , Hamada , M. and Takeuchi , T. Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes . J. Antibiot. , 29 , 9799 ( 1976 ).
  • 9
    ) Suda , H. , Aoyagi , T. , Takeuchi , T. and Umezawa , H. Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomers . Arch. Biochem. Biophys. , 177 , 196200 ( 1976 ).
  • 10
    ) Leyhausen , G. , Schuster , D. K. Vaith , P. , Zahn , R. K. Umezawa , H. , Falke , D. and Mïiller , W. E. G. Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin . Biochem. Pharmacol. , 32 , 10511057 ( 1983 ).
  • 11
    ) Kuramochi , H. , Motegi , A. , Iwabuchi , M. , Takahashi , K. , Horinishi , H. and Umezawa , H. Action of ubenimex on aminopeptidase activities in spleen cells and peritoneal macrophages from mice . J. Antibiot. , 40 , 16051611 ( 1987 ).
  • 12
    ) Abe , F. , Shibuya , K. , Uchida , M. , Takahashi , K. , Horinishi , H. , Matsuda , A. , Ishizuka , M. , Takeuchi , T. and Umezawa , H. Effect of bestatin on syngeneic tumors in mice . Gann , 75 , 8994 ( 1984 ).
  • 13
    ) Schlorlemmer , H-U. , Bosslet , K. , Dickneite , G. , Luben , G. and Sedlacek , H. H. Studies on the mechanisms of action of the immunomodulator bestatin in various screening test systems . Behring Inst. Mitt. , 74 , 157173 ( 1984 ).
  • 14
    ) Ishizuka , M. , Masuda , T. , Kanbayashi , N. , Fukusawa , S. , Takeuchi , T. , Aoyagi , T. and Umezawa , H. Effect of bestatin on mouse immune system and experimental murine tumors . J. Antibiot. , 33 , 642652 ( 1980 ).
  • 15
    ) Miwa , H. , Oka , T. , Tsurumi , T. , Sakae , Y. and Orita , K. Experimental and clinical studies of bestatin as an immunomodulator . Jpn. J. Cancer Chemother. , 9 , 10191024 ( 1982 ).
  • 16
    ) Ikeda , S. , Miyasato , H. , Saito , K. , Nakayama , H. and Tajima , K. Phase I study of bestatin, (II) clinical trial of bestatin in malignant skin tumors . InSmall Molecular Immunomodifiers of Microbial Origin,” ed. H. Umezawa , pp. 143158 ( 1981 ). Pergamon Press , New York ).
  • 17
    ) Majima , H. Phase I and preliminary phase II clinical trials of bestatin . InSmall Molecular Immunomodifiers of Microbial Origin ,“ ed. H. Umezawa , pp. 173178 ( 1981 ). Pergamon Press , New York ).
  • 18
    ) Bruley-Rosset , M. , Florentin , I. , Kiger , N. , Schulz , J. and Mathe , G. Restoration of impaired immune functions of aged animals by chronic bestatin treatment . Immunology , 38 , 7583 ( 1979 ).
  • 19
    ) Saito , K. , Takegoshi , K. , Aoyagi , T. , Umezawa , H. and Nagai , Y. Stimulatory effect of bestatin, a new specific inhibitor of aminopeptidase, on the blastogenesis of guinea pig lymphocytes . Cell. Immunol. , 40 , 247262 ( 1978 ).
  • 20
    ) Schorlemmer , H. U. , Bosslet , K. and Sedlacek , H. H. The ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes . Cancer Res. , 43 , 41484153 ( 1983 ).
  • 21
    ) Dunlap , B. E. , Dunlap , S. A. and Rich , D. H. Effect of bestatin on in vitro responses of murine lymphocytes to T-cell stimuli . Scand. J. Immunol. , 20 , 237245 ( 1984 ).
  • 22
    ) Talmadge , J. E. , Lenz , B. F. , Pennington , R. , Long , C. , Phillips , H. , Schneider , M. and Tribble , H. Immunomodulatory and therapeutic properties of bestatin in mice . Cancer Res. , 46 , 45054510 ( 1986 ).
  • 23
    ) Albini , A. , Iwamoto , Y. , Kleinman , H. K. , Martin , G. R. , Aaronson , S. A. Kozlowski , J. M. and McEwan , R. N. A rapid in vitro assay for quantitating the invasive potential of tumor cells . Cancer Res. , 47 , 32393245 ( 1987 ).
  • 24
    ) Koyama , M. Pharmacokmetics and biotransformation of bestatin . InRecent Results on Bestatin ,“ ed. H. Umezawa , pp. 4150 ( 1986 ). Japan Antibiotics Res. Assoc. , Tokyo ).
  • 25
    ) Talmadge , J. E. , Koyama , M. , Matsuda , A. , Long , C. and Abe , F. Immunotherapeutic properties of bestatin, mechanism of activity . InRecent Results on Bestatin ,“ ed. H. Umezawa , pp. 825 ( 1986 ). Japan Antibiotics Res. Assoc. , Tokyo ).
  • 26
    ) Morahan , P. S. , Edelson , P. J. and Gass , K. Changes in macrophages ectoenzymes associated with antitumor activity . J. Immunol. , 125 , 13121317 ( 1980 ).
  • 27
    ) Wachsmuth , E. D. Aminopeptidase as a marker for macrophage differentiation . Exp. Cell Res. , 96 , 409412 ( 1975 ).
  • 28
    ) Poole , A. R. , Tutman , K. J. , Recklies , A. D. and Stoker , T. A. Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas . Nature , 273 , 545547 ( 1978 ).
  • 29
    ) Recklies , A. D. , Mort , J. S. and Poole , A. R. Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization . Cancer Res. , 42 , 10261032 ( 1982 ).
  • 30
    ) Sloane , B. F. , Honn , K. V. , Sadler , J. C. , Turner , W. A. , Kimpson , J. J. and Taylor , J. D. Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential . Cancer Res. , 42 , 980986 ( 1982 ).
  • 31
    ) Robertson , D. M. and Williams , D. C. In vitro evidence for neutral collagenase activity in an invasive mammalian tumor . Nature , 221 , 259260 ( 1969 ).
  • 32
    ) Hashimoto , K. , Yamanishi , Y. , Maeyens , E. , Dabbous , M. K. and Kanzaki , T. Collagenolytic activities of squamous cell carcinoma of the skin . Cancer Res. , 33 , 27902801 ( 1973 ).
  • 33
    ) Liotta , L. A. , Tryggvason , K. , Garbisa , S. , Hart , I. , Foltz , C. M. and Shafie , S. Metastatic potential correlates with enzymatic degradation of besement membrane collagen . Nature , 284 , 6768 ( 1980 ).
  • 34
    ) Eisenbach , L. , Segal , S. and Feldman , M. Proteolytic enzymes in tumor matastasis. II. Collagenase type IV activity in subcellular fractions of cloned tumor cell populations . J. Natl. Cancer Inst. , 74 , 8793 ( 1985 ).
  • 35
    ) Dano , K. , Andreasen , P. A. , Grondahl-Hansen , J. , Kristensen , P. , Nielsen , L. S. and Skriver , L. Plasminogen activators, tissue degradation and cancer . Adv. Cancer Res. , 44 , 139266 ( 1985 ).