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REFERENCES

  • 1
    ) Tsuda , H. , Hirohashi , S. , Shimosato , Y. , Terada , M. and Hasegawa , H. Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma . Gastroenterology , 95 , 16641666 ( 1988 ).
  • 2
    ) Yasui , H. , Hino , O. , Ohtake , K. , Machinami , R. and Kitagawa , T. Clonal growth of hepatitis B virus-integrated hepatocytes in cirrhotic liver nodule . Cancer Res. , 52 , 68106814 ( 1992 ).
  • 3
    ) Kanai , T. , Hirohashi , S. , Upton , M. P. , Noguchi , M. , Kishi , K. , Makuuchi , M. , Yamasaki , S. , Hasegawa , H. , Takayasu , K. , Moriyama , N. and Shimosato , Y. Pathology of small hepatocellular carcinoma: a proposal for a new gross classification . Cancer , 60 , 810819 ( 1987 ).
  • 4
    ) Sakamoto , M. , Hirohashi , S. and Shimosato , Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma . Hum. Pathol. , 22 , 172178 ( 1991 ).
  • 5
    ) Wang , H. P. and Rogler , C. E. Deletion in human chromosome arm 11p and 13q in primary hepatocellular carcinoma . Cytogenet. Cell Genet. , 48 , 7278 ( 1988 ).
  • 6
    ) Buetow , K. H. , Murray , J. C. , Israel , J. L. , London , W. T. , Smith , M. , Kew , M. , Blanquest , V. , Brechot , C. , Redeker , A. and Govindarajah , S. Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma . Proc. Natl. Acad. Sci. USA , 86 , 88528856 ( 1989 ).
  • 7
    ) Tsuda , H. , Zhang , W. , Shimosato , Y. , Yokota , J. , Terada , M. , Sugimura , T. , Miyamura , T. and Hirohashi , S. Allelic loss on chromosome 16 associated with progression of human hepatocellular carcinoma . Proc. Natl. Acad. Sci. USA , 87 , 67916794 ( 1990 ).
  • 8
    ) Zhang , W. , Hirohashi , S. , Tsuda , H. , Shimosato , Y. , Yokota , J. , Terada , M. and Sugimura , T. Frequent loss of heterozygosity on chromosome 16 and 4 in human hepatocellular carcinoma . Jpn. J. Cancer Res. , 81 , 108111 ( 1990 ).
  • 9
    ) Fujimori , M. , Tokino , T. , Hino , O. , Kitagawa , T. , Imamura , T. , Okamoto , E. , Mitsunobu , M. , Ishikawa , T. , Nakagama , H. , Harada , H. , Yagura , M. , Matsubara , K. and Nakamura , Y. Allelotype study of primary hepatocellular carcinoma . Cancer Res. , 51 , 8993 ( 1991 ).
  • 10
    ) Simon , D. , Knowles , B. B. and Weith , A. Abnormalities of chromosome 1 and loss of heterozygosity of 1p in primary hepatomas . Oncogene , 6 , 765770 ( 1991 ).
  • 11
    ) Emi , M. , Fujiwara , Y. , Nakajima , T. , Tsuchiya , E. , Tsuda , H. , Hirohashi , S. , Maeda , Y. , Tsuruta , K. , Miyaki , M. and Nakamura , Y. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer . Cancer Res. , 52 , 53685372 ( 1992 ).
  • 12
    ) Emi , M. , Fujiwara , Y. , Ohata , H. , Tsuda , H. , Hirohashi , S. , Koike , M. , Miyaki , M. , Monden , M. and Nakamura , Y. Allelic loss at chromosome band 8p21.3-p22 is associated with progression of hepatocellular carcinoma . Gene Chrom. Cancer , 7 , 152157 ( 1993 ).
  • 13
    ) Murakami , Y. , Hayashi , K. , Hirohashi , S. and Sekiya , T. Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas . Cancer Res. , 51 , 55205525 ( 1991 ).
  • 14
    ) Oda , T. , Tsuda , H. , Scarpa , A. , Sakamoto , M. and Hirohashi , S. Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma . Cancer Res. , 52 , 36743678 ( 1992 ).
  • 15
    ) Oda , T. , Tsuda , H. , Scarpa , A. , Sakamoto , M. and Hirohashi , S. p53 gene mutation spectrum in hepatocellular carcinoma . Cancer Res. , 52 , 63586364 ( 1992 ).
  • 16
    ) Oda , T. , Tsuda , H. , Sakamoto , M. and Hirohashi , S. Different mutation of the p53 gene in nodule-in-nodule hepatocellular carcinoma as evidence for multistage progression . Cancer Lett. , 83 , 197200 ( 1994 ).
  • 17
    ) Jones , P. A. and Buckley , J. D. The role of DNA methylation in cancer . Adv. Cancer Res. , 54 , 123 ( 1990 ).
  • 18
    ) Counts , J. L. and Goodman , J. I. Alterations in DNA methylation may play a variety of roles in carcinogenesis . Cell , 83 , 1315 ( 1995 ).
  • 19
    ) Gama-Sosa , M. A. , Slagel , V. A. , Trewyn , R. W. , Oxenhandler , R. , Kuo , K. C. , Gehrke , C. W. and Ehrlich , M. The 5-methylcytosine content of DNA from human tumors . Nucleic Acids Res. , 11 , 68836894 ( 1983 ).
  • 20
    ) Goelz , S. E. , Vogelstein , B. , Hamilton , S. R. and Feinberg , A. P. Hypomethylation of DNA from benign and malignant human colon neoplasms . Science , 228 , 189190 ( 1985 ).
  • 21
    ) Kautiainen , T. L. and Jones , P. A. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture . J. Biol. Chem. , 261 , 15941598 ( 1986 ).
  • 22
    ) El-Deiry , W. S. , Nelkin , B. D. , Celano , P. , Yen , R.-W. C. , Falco , J. P. , Hamilton , S. R. and Baylin , S. B. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer . Proc. Natl. Acad. Sci. USA , 88 , 34703474 ( 1991 ).
  • 23
    ) Bustros , A. D. , Nelkin , B. D. , Silverman , A. , Ehrlich , G. , Poiesz , B. and Baylin , S. B. The short arm of chromosome 11 is a “hot spot” for hypermethylation in human neoplasia . Proc. Natl. Acad. Sci. USA , 85 , 56935697 ( 1988 ).
  • 24
    ) Makos , M. , Nelkin , B. D. , Lerman , M. I. , Latif , F. , Zbar , B. and Baylin , S. B. Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer . Proc. Natl. Acad. Sci. USA , 89 , 19291933 ( 1992 ).
  • 25
    ) Makos , M. , Nelkin , B. D. , Reiter , R. E. , Gnarra , J. R. , Brooks , J. , Isaacs , W. , Linehan , M. and Baylin , S. B. Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors . Cancer Res. , 53 , 27192722 ( 1993 ).
  • 26
    ) Pieretti , M. , Powell , D. E. , Gallion , H. H. , Conway , P. S. , Case , E. A. and Turker , M. S. Hypermethylation at a chromosome 17 “hot spot” is a common event in ovarian cancer . Hum. Pathol. , 26 , 398401 ( 1995 ).
  • 27
    ) Makos , M. , Nelkin , B. D. , Chazin , V. R. , Cavenee , W. K. , Brodeur , G. M. and Baylin , S. B. DNA hypermethylation is associated with 17p allelic loss in neural tumors . Cancer Res. , 53 , 27152718 ( 1993 ).
  • 28
    ) Buchhagen , D. L. , Qiu , L. and Etkind , P. Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3pl4.3-3p21.3 in sporadic breast-cancer development . Int. J. Cancer , 57 , 473479 ( 1994 ).
  • 29
    ) Vachtenheim , J. , Horakova , I. and Novotna , H. Hypomethylation of CCGG sites in the 3′ region of H-ras protooncogene is frequent and is associated with H-ras allelic loss in non-small cell lung cancer . Cancer Res. , 54 , 11451148 ( 1994 ).
  • 30
    ) Shen , J.-C. , Rideout Ill , W. M. and Jones , P. A. High frequency mutagenesis by a DNA methyltransferase . Cell , 71 , 10731080 ( 1992 ).
  • 31
    ) Yang , A. S. , Shen , J.-C. , Zingg , J.-M. , Mi , S. and Jones , P. A. HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair . Nucleic Acids Res. , 23 , 13801387 ( 1995 ).
  • 32
    ) Antequera , F. , Boyes , J. and Bird , A. High levels of denovo methylation and altered chromatin structure at CpG islands in cell lines . Cell , 62 , 503514 ( 1990 ).
  • 33
    ) Bird , A. P. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines . Nature , 321 , 209213 ( 1986 ).
  • 34
    ) Keshet , I. , Lieman-Hurwitz , J. and Cedar , H. DNA methylation affects the formation of active chromatin . Cell , 44 , 535543 ( 1986 ).
  • 35
    ) Edmondson , H. and Steiner , P. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies . Cancer , 7 , 462503 ( 1954 ).
  • 36
    ) Sambrook , J. , Fritsch , E. F. and Maniatis , T. “Molecular Cloning: a Laboratory Manual,” pp. E.3E.4 ( 1989 ). Cold Spring Harbor Lab. , NY .
  • 37
    ) Harris , P. , Lalande , M. , Stroh , H. , Bruns , G. , Flint , A. and Latt , S. A. A. Construction of a chromosome 16- enriched phage library and characterization of several DNA segments from 16p . Hum. Genet. , 77 , 95103 ( 1987 ).
  • 38
    ) Hyland , V. J. , Grist , G. and Sutherland , G. R. Restriction fragment length polymorphisms detected by anonymous DNA probes mapped to defined intervals of human chromosome 16 . Hum. Genet. , 79 , 277279 ( 1988 ).
  • 39
    ) Westphal , E.-M. , Natt , E. , Grimm , T. , Odievre , M and Scherer , G. The human tyrosine aminotransferase gene: characterization of restriction fragment length polymorphisms and haplotype analysis in a family with tyrosinemia type II . Hum. Genet. , 79 , 260264 ( 1988 ).
  • 40
    ) Bufton , L. , Mohandas , T. K. , Magenis , R. E. , Sheehy , R. , Bestwick , R. K. and Litt , M. A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library . Hum. Genet. , 74 , 425431 ( 1986 ).
  • 41
    ) Doggett , N. A. , Goodwin , L. A. , Tesmer , J. G. , Meincke , L. J. , Bruce , D. C. , Clark , L. M. , Altherr , M. R. , Ford , A. A. , Chi , H. C. , Marrone , B. L. , Longmire , J. L. , Lane , S. A. , Whitmore , S. A. , Lowenstein , M. G. , Sutherland , R. D. , Mundt , M. O. , Knill , E. H. , Bruno , W. J. , Macken , C. A. , Torney , D. C. , Wu , J.-R. , Griffith , J. , Sutherland , G. R. , Deaven , L. L. , Callen , D. F. and Moyzis , R. K. An integrated physical map of human chromosome 16 . Nature , 377 , 335364 ( 1995 ).
  • 42
    ) van der Ploeg , L. H. T. and Flavell , R. A. DNA methylation in the human γδβ-globin locus in erythroid and non-erythroid tissue . Cell , 19 , 947958 ( 1980 ).
  • 43
    ) Devilee , P. , Vliet , M. V. , Sloun , P. V. , Dijkshoorn , N. K. , Hermans , J. , Pearson , P. L. and Cornelisse , C. J. Allelo-type of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q . Oncogene , 6 , 17051711 ( 1991 ).
  • 44
    ) Cleton-Jansen , A. M. , Moerland , E. W. , Kuipers-Dijkshoorn , N. J. , Callen , D. F. , Sutherland , G. R. , Hansen , B. , Devilee , P. and Cornelisse , C. At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer . Genes Chrom. Cancer , 9 , 101107 ( 1994 ).
  • 45
    ) Sakai , T. , Toguchida , J. , Ohtani , N. , Yandell , D. W. , Rapaport , J. M. and Dryja , T. P. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene . Am. J. Hum. Genet. , 48 , 880888 ( 1991 ).
  • 46
    ) Herman , J. G. , Latif , F. , Weng , Y. , Lerman , M. I. , Zbar , B. , Liu , S. , Samid , D. , Duan , D.-S. R. , Gnarra , J. R. , Linehan , W. M. and Baylin , S. B. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma . Proc. Natl. Acad. Sci. USA , 91 , 97009704 ( 1994 ).
  • 47
    ) Herman , J. G. , Jen , J. , Merlo , A. and Baylin , S. B. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B1 . Cancer Res. , 56 , 722727 ( 1996 ).
  • 48
    ) Merlo , A. , Herman , J. G. , Mao , L. , Lee , D. J. , Gabrielson , E. , Burger , P. C. , Baylin , S. B. and Sidransky , D. 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers . Nat. Med. , 1 , 686692 ( 1995 ).
  • 49
    ) Herman , J. G. , Merlo , A. , Mao , L. , Lapidus , R. G. , Issa , J.-P. J. , Davidson , N. E. , Sidransky , D. and Baylin , S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers . Cancer Res. , 55 , 45254530 ( 1995 ).
  • 50
    ) Yoshiura , K. , Kanai , Y. , Ochiai , A. , Shimoyama , Y. , Sugimura , T. and Hirohashi , S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas . Proc. Natl. Acad. Sci. USA , 92 , 74167419 ( 1995 ).
  • 51
    ) Wales , M. M. , Biel , M. A. , Deiry , W. E. , Nelkin , B. D. , Issa , J.-P. , Cavenee , W. K. , Kuerbitz , S. J. and Baylin , S. B. p53 activates expression of HIC-1, a new candidate tumor suppressor gene on 17p13.3 . Nat. Med. , 1 , 570577 ( 1995 ).
  • 52
    ) Feinberg , A. P. and Vogelstein , B. Hypomethylation of ras oncogenes in primary human cancers . Biochem. Biophys. Res. Commun. , 111 , 4754 ( 1983 ).
  • 53
    ) Cheah , M. S. C. , Wallace , C. D. and Hoffman , R. M. Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc oncogene . J. Natl. Cancer Inst. , 73 , 10571065 ( 1984 ).
  • 54
    ) Laird , P. W. , Jackson-Grusby , L. , Fazeli , A. , Dickinson , S. L. , Jung , W. E. , Li , E. , Weinberg , R. A. and Jaenisch , R. Suppression of intestinal neoplasia by DNA hypomethylation . Cell , 81 , 197205 ( 1995 ).
  • 55
    ) Grossmann , M. , Hoermann , R. , Weiss , M. , Jauch , K. W. , Oertel , H. , Staebler , A. , Mann , K. and Engelhardt , D. Spontaneous regression of hepatocellular carcinoma . Am. J. Gastroenterol. , 90 , 15001503 ( 1995 ).