• Open Access

Lung Cancer Patients Have Increased 8-Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA

Authors

  • Masaaki Inoue,

    1. Department of Environmental Oncology, Institute of Industrial Ecological Sciences
    2. Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555
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  • Toshihiro Osaki,

    1. Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555
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  • Masayuki Noguchi,

    1. Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045
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    • Department of Pathology, Institute of Basic Medical Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575.

  • Setsuo Hirohashi,

    1. Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045
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  • Kosei Yasumoto,

    1. Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555
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  • Hiroshi Kasai

    Corresponding author
    1. Department of Environmental Oncology, Institute of Industrial Ecological Sciences
    • 5To whom all correspondence should be addressed.

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Abstract

The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).

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