Department of Pathology, Institute of Basic Medical Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575.
Lung Cancer Patients Have Increased 8-Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
Article first published online: 23 AUG 2005
Japanese Journal of Cancer Research
Volume 89, Issue 7, pages 691–695, July 1998
How to Cite
Inoue, M., Osaki, T., Noguchi, M., Hirohashi, S., Yasumoto, K. and Kasai, H. (1998), Lung Cancer Patients Have Increased 8-Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA. Japanese Journal of Cancer Research, 89: 691–695. doi: 10.1111/j.1349-7006.1998.tb03272.x
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- (Received February 16, 1998/Revised May 14, 1998/Accepted May 27, 1998)
- key words;
- Oxidative DNA damage;
- Lung cancer
The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).