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Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) Study

  1. Yoshinori Ito1,*,
  2. Kenji Wakai2,
  3. Koji Suzuki1,
  4. Akiko Tamakoshi2,
  5. Nao Seki3,
  6. Masahiko Ando2,
  7. Yoshikazu Nishino4,
  8. Takaaki Kondo5,
  9. Yoshiyuki Watanabe6,
  10. Kotaro Ozasa6,
  11. Yoshiyuki Ohno2,
  12. JACC Study Group1

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1349-7006.2003.tb01352.x

Issue

Cancer Science

Cancer Science

Volume 94, Issue 1, pages 57–63, January 2003

Additional Information

How to Cite

Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., Ohno, Y. and JACC Study Group (2003), Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) Study. Cancer Science, 94: 57–63. doi: 10.1111/j.1349-7006.2003.tb01352.x

Author Information

  1. 1

    Department of Public Health, Fujita Health University School of Health Sciences, 1–98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470–1192

  2. 2

    Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466–8550

  3. 3

    Division of Public Health, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Science, 1–757 Asahimachidori, Niigata 951–8510

  4. 4

    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2–1 Seiryomachi, Aoba-ku, Sendai 980–8575

  5. 5

    Department of Public Health/Heath Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466–8550

  6. 6

    Department of Social Medicine and Cultural Sciences, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602–8566

*E-mail: yoshiito@fujita-hu.ac.jp

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. (Received August 1, 2002/Revised October 7, 2002/Accepted October 23, 2002)

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To investigate whether high serum levels of carotenoids, tocopherols, and folic acid decrease risk of lung cancer in Japanese, we conducted a case-control study nested in the Japan Collaborative Cohort (JACC) Study. A total of 39 140 subjects provided serum samples at baseline between 1988 and 1990. We identified 147 cases (113 males and 34 females) of death from lung cancer during an 8-year follow-up. Of the subjects who survived to the end of this follow-up, 311 controls (237 males and 74 females) were selected, matched to each case of lung cancer death for gender, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratios (ORs) for lung cancer death were estimated using conditional logistic models. The risk of lung cancer death for the highest quartile of serum α-carotene, β-carotene, lycopene, β-cryptoxanthin, and canthaxanthin was significantly or marginally significantly lower than for the lowest quartile: the ORs, adjusted for smoking and other covariates, were 0.35 (95% confidence interval (Cl), 0.14–0.88), 0.21 (0.08–0.58), 0.46 (0.21–1.04), 0.44 (0.17–1.16) and 0.37 (0.15–0.91), respectively. The ORs for the highest serum levels of zeaxanthin/lutein and folic acid tended to be low, but the differences were not statistically significant. Serum total cholesterol was also inversely related to risk of lung cancer death: the OR for the highest vs. the lowest quartile was 0.39 (95% Cl, 0.19–0.79). Higher serum levels of carotenoids such as α- and β-carotenes may play a role in preventing death from lung cancer among Japanese. (Cancer Sci 2003; 94: 57–63)

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