• Open Access

Chemokines in tumor progression and metastasis

Authors

  • Toshiyuki Tanaka,

    1. Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan
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  • Zhongbin Bai,

    1. Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan
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  • Yuttana Srinoulprasert,

    1. Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan
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  • BoGi Yang,

    1. Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan
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  • Haruko Hayasaka,

    1. Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan
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  • Masayuki Miyasaka

    Corresponding author
    1. Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2, Suita, 565-0871, Japan
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To whom correspondence should be addressed. E-mail: mmiyasak@orgctl.med.osaka-u.ac.jp

Abstract

Although chemokines have been thought of primarily as leukocyte attractants, a growing body of evidence indicates that they also contribute to a number of tumor-related processes, such as tumor cell growth, angiogenesis/angiostasis, local invasion, and metastasis. The current knowledge of the possible involvement of chemokines and their receptors in these cellular events are reviewed here. The operating mechanism of chemokines in relation to metastatic processes in vivo are also discussed. (Cancer Sci 2005; 96: 317–322)

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