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Regulation of cancer cell motility through actin reorganization

  1. Daisuke Yamazaki1,2,
  2. Shusaku Kurisu1,2,
  3. Tadaomi Takenawa1,2,*

Article first published online: 29 JUL 2005

DOI: 10.1111/j.1349-7006.2005.00062.x

Issue

Cancer Science

Cancer Science

Volume 96, Issue 7, pages 379–386, July 2005

Additional Information

How to Cite

Yamazaki, D., Kurisu, S. and Takenawa, T. (2005), Regulation of cancer cell motility through actin reorganization. Cancer Science, 96: 379–386. doi: 10.1111/j.1349-7006.2005.00062.x

Author Information

  1. 1

    Department of Biochemistry, Institute of Medical Science, University of Tokyo 4-6-1 Shirokanedai, Minato-ku, Tokyo; and

  2. 2

    CREST, Japan Science and Technology Corporation, 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: takenawa@ims.u-tokyo.ac.jp

Publication History

  1. Issue published online: 29 JUL 2005
  2. Article first published online: 29 JUL 2005
  3. (Received March 8, 2005/Revised April 8, 2005/Accepted April 26, 2005/Online publication July 22, 2005)

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References

  • 1
    Ridley AJ, Schwartz MA, Burridge K et al. Cell migration: integrating signals from front to back. Science 2003; 302: 1704–9.
  • 2
    Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112: 453–65.
  • 3
    Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003; 3: 921–30.
  • 4
    Kundra V, Escobedo JA, Kazlauskas A et al. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature 1994; 367: 474–6.
  • 5
    Huttenlocher A, Sandborg RR, Horwitz AF. Adhesion in cell migration. Curr Opin Cell Biol 1995; 7: 697–706.
  • 6
    Lauffenburger DA. Cell motility. Making connections count. Nature 1996; 383: 390–1.
  • 7
    Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004; 265: 23–32.
  • 8
    Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629–35.
  • 9
    Weiner OD et al. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 2002; 4: 509–13.
  • 10
    Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. Lipid products of PI(3) Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol 2002; 4: 513–8.
  • 11
    Small JV, Stradal T, Vignal E, Rottner K. The lamellipodium: where motility begins. Trends Cell Biol 2002; 12: 112–20.
  • 12
    Nobes CD, Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 1999; 144: 1235–44.
  • 13
    Alblas J, Ulfman L, Hordijk P, Koenderman L. Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol Biol Cell 2001; 12: 2137–45.
  • 14
    Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3: 362–74.
  • 15
    Friedl P, Hegerfeldt Y, Tusch M. Collective cell migration in morphogenesis and cancer. Int J Dev Biol 2004; 48: 441–9.
  • 16
    Lozano E, Betson M, Braga VM. Tumor progression: Small GTPases and loss of cell–cell adhesion. Bioessays 2003; 25: 452–63.
    Direct Link:
  • 17
    Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol 2004; 16: 14–23.
  • 18
    Tamariz E, Grinnell F. Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol Biol Cell 2002; 13: 3915–29.
  • 19
    Wolf K, Mazo I, Leung H et al. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 2003; 160: 267–77.
  • 20
    Friedl P, Borgmann S, Brocker EB. Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement. J Leukoc Biol 2001; 70: 491–509.
  • 21
    Francis K, Palsson B, Donahue J, Fong S, Carrier E. Murine Sca-1(+)/Lin(−) cells and human KG1a cells exhibit multiple pseudopod morphologies during migration. Exp Hematol 2002; 30: 460–3.
  • 22
    Wang W, Wyckoff JB, Frohlich VC et al. Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res 2002; 62: 6278–88.
  • 23
    Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 2003; 5: 711–9.
  • 24
    Kurisu S, Suetsugu S, Yamazaki D, Yamaguchi H, Takenawa T. Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells. Oncogene 2005; 24: 1309–19.
  • 25
    Worthylake RA, Lemoine S, Watson JM, Burridge K. RhoA is required for monocyte tail retraction during transendothelial migration. J Cell Biol 2001; 154: 147–60.
  • 26
    Takenawa T, Miki H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci 2001; 114: 1801–9.
  • 27
    Miki H, Takenawa T. Regulation of actin dynamics by WASP family proteins. J Biochem (Tokyo) 2003; 134: 309–13.
  • 28
    Kenney D, Cairns L, Remold-O'Donnell E, Peterson J, Rosen FS, Parkman R. Morphological abnormalities in the lymphocytes of patients with the Wiskott–Aldrich syndrome. Blood 1986; 68: 1329–32.
  • 29
    Molina IJ, Kenney DM, Rosen FS, Remold-O'Donnell E. T cell lines characterize events in the pathogenesis of the Wiskott–Aldrich syndrome. J Exp Med 1992; 176: 867–74.
  • 30
    Miki H, Miura K, Takenawa T. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J 1996; 15: 5326–35.
  • 31
    Miki H, Sasaki T, Takai Y, Takenawa T. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature 1998; 391: 93–6.
  • 32
    Rohatgi R, Ma L, Miki H et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 1999; 97: 221–31.
  • 33
    Miki H, Suetsugu S, Takenawa T. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J 1998; 17: 6932–41.
  • 34
    Suetsugu S, Miki H, Takenawa T. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem Biophys Res Commun 1999; 260: 296–302.
  • 35
    Bear JE, Rawls JF, Saxe CL3rd. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. J Cell Biol 1998; 142: 1325–35.
  • 36
    Miki H, Yamaguchi H, Suetsugu S, Takenawa T. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature 2000; 408: 732–5.
  • 37
    Miki H, Takenawa T. WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. Biochem Biophys Res Commun 2002; 293: 93–9.
  • 38
    Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 2002; 418: 790–3.
  • 39
    Bompard G, Caron E. Regulation of WASP/WAVE proteins: making a long story short. J Cell Biol 2004; 166: 957–62.
  • 40
    Yamazaki D, Suetsugu S, Miki H et al. WAVE2 is required for directed cell migration and cardiovascular development. Nature 2003; 424: 452–6.
  • 41
    Suetsugu S, Yamazaki D, Kurisu S, Takenawa T. Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev Cell 2003; 5: 595–609.
  • 42
    Oikawa T, Yamaguchi H, Itoh T et al. PtdIns (3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol 2004; 6: 420–6.
  • 43
    Svitkina TM, Borisy GG. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J Cell Biol 1999; 145: 1009–26.
  • 44
    Buccione R, Orth JD, McNiven MA. Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat Rev Mol Cell Biol 2004; 5: 647–57.
  • 45
    Linder S, Aepfelbacher M. Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 2003; 13: 376–85.
  • 46
    Linder S, Nelson D, Weiss M, Aepfelbacher M. Wiskott–Aldrich syndrome protein regulates podosomes in primary human macrophages. Proc Natl Acad Sci USA 1999; 96: 9648–53.
  • 47
    Yamaguchi H, Lorenz M, Kempiak S et al. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 2005; 168: 441–52.
  • 48
    Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 2005; 15: 87–96.
  • 49
    Eccles SA. Targeting key steps in metastatic tumour progression. Curr Opin Genet Dev 2005; 15: 77–86.
  • 50
    Walker K, Olson MF. Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Curr Opin Genet Dev 2005; 15: 62–8.
  • 51
    Zigmond SH. Formin-induced nucleation of actin filaments. Curr Opin Cell Biol 2004; 16: 99–105.
  • 52
    Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD. Drosophila Spire is an actin nucleation factor. Nature 2005; 433: 382–8.
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