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Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis

  1. Ponlatham Chaiyarit1,
  2. Ning Ma2,
  3. Yusuke Hiraku3,
  4. Somchai Pinlaor4,5,
  5. Puangrat Yongvanit5,6,
  6. Darunee Jintakanon7,
  7. Mariko Murata3,
  8. Shinji Oikawa3,
  9. Shosuke Kawanishi3,*

Article first published online: 26 AUG 2005

DOI: 10.1111/j.1349-7006.2005.00096.x

Issue

Cancer Science

Cancer Science

Volume 96, Issue 9, pages 553–559, September 2005

Additional Information

How to Cite

Chaiyarit, P., Ma, N., Hiraku, Y., Pinlaor, S., Yongvanit, P., Jintakanon, D., Murata, M., Oikawa, S. and Kawanishi, S. (2005), Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis. Cancer Science, 96: 553–559. doi: 10.1111/j.1349-7006.2005.00096.x

Author Information

  1. 1

    Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand;

  2. 2

    Department of Anatomy and

  3. 3

    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514-8507, Japan; and

  4. 4

    Department of Parasitology,

  5. 5

    Liver Fluke and Cholangiocarcinoma Research Center,

  6. 6

    Department of Biochemistry, and

  7. 7

    Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

* To whom correspondence should be addressed. E-mail: kawanisi@doc.medic.mie-u.ac.jp

Publication History

  1. Issue published online: 26 AUG 2005
  2. Article first published online: 26 AUG 2005
  3. (Received April 22, 2005/Revised June 24, 2005/Accepted June 27, 2005/Online publication September 5, 2005)

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Oral lichen planus (OLP) is a chronic inflammatory disease, which has been clinically associated with development to oral cancer. A double immunofluorescence labeling study found that 8-nitroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) accumulated in oral epithelium in OLP and oral squamous cell carcinoma (OSCC) biopsy specimens, whereas little or no immunoreactivity was observed in normal oral mucosa. Colocalization of 8-nitroguanine and inducible nitric oxide synthase (iNOS) was found in oral epithelium of OLP and OSCC. Immunoreactivity of 3-nitrotyrosine, which is formed by protein tyrosine nitration and is considered to be a biochemical marker for inflammation, was also observed in oral epithelial cells and colocalized with 8-nitroguanine. Accumulation of p53 was more strongly observed in oral epithelium in OSCC than OLP, whereas there was no p53 accumulation in normal oral mucosa. Our findings demonstrate that iNOS-dependent DNA damage in OLP may lead to p53 accumulation in not only OLP but also OSCC. We conclude that the formation of potentially mutagenic DNA lesions including 8-nitroguanine and 8-oxodG may contribute to the development of oral cancer from OLP. (Cancer Sci 2005; 96: 553 –559)

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