• 1
    Jemal A, Murray T, Ward E et al . Cancer statistics, 2005. CA Cancer J Clin 2005; 55: 1030.
  • 2
    American Cancer Society. Cancer Facts and Figures 2006. 2006. [Cited 16 November 2006.] Available from URL:
  • 3
    Song HY, Liu YK, Feng JT et al . Proteomic analysis on metastasis-associated proteins of human hepatocellular carcinoma tissues. Cancer Res Clin Oncol 2006; 132: 928.
  • 4
    Li DQ, Wang L, Fei F et al . Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry. Proteomics 2006; 6: 335268.
  • 5
    Wu W, Tang X, Hu W, Lotan R, Hong WK, Mao L. Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry. Clin Exp Metastasis 2002; 19: 31926.
  • 6
    Jiang DF, Ying WT, Lu YL et al . Identification of metastasis-associated proteins by proteomic analysis and functional exploration of interleukin-18 in metastasis. Proteomics 2003; 3: 72437.
  • 7
    Chu YW, Yang PC, Yang SC et al . Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997; 17: 35360.
  • 8
    Ho CC, Huang PH, Huang HY, Chen YH, Yang PC, Hsu SM. Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am J Pathol 2002; 161: 164756.
  • 9
    Shih JY, Yang SC, Hong TM et al . Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. J Natl Cancer Inst 2001; 93: 1392400.
  • 10
    Chang CC, Shih JY, Jeng YM et al . Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. J Natl Cancer Inst 2004; 96: 36475.
  • 11
    Sakaguchi M, Miyazaki M, Takaishi M et al . S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes. J Cell Biol 2003; 163: 82535.
  • 12
    Kanamori T, Takakura K, Mandai M et al . Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours. Mol Hum Reprod 2004; 10: 73542.
  • 13
    Rety S, Osterloh D, Arie JP et al . Structural basis of the Ca2+-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I. Structure 2000; 8: 17584.
  • 14
    Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acids Res 2001; 29: 20027.
  • 15
    Fountoulakis M, Tsangaris G, Oh J et al . Protein profile of the HeLa cell line. J Chromatogr A 2004; 1038: 24765.
  • 16
    Chen G, Gharib TG, Huang CC et al . Discordant protein and mRNA expression in lung adenocarcinomas. Mol Cell Proteomics 2002; 1: 30413.
  • 17
    Tian Q, Stepaniants SB, Mao M et al . Integrated genomic and proteomic analyses of gene expression in mammalian cells. Mol Cell Proteomics 2004; 3: 9609.
  • 18
    Steeg PS, Bevilacqua G, Kopper L et al . Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988; 80: 2004.
  • 19
    Leone A, Flatow U, VanHoutte K, Steeg PS. Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene 1993; 8: 232533.
  • 20
    Nakayama T, Ohtsuru A, Nakao K et al . Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. J Natl Cancer Inst 1992; 84: 134954.
  • 21
    Fu Z, Smith PC, Zhang LZ et al . Effects of Raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 2003; 95: 87899.
  • 22
    Heizmann CW, Fritz G, Schafer BW. S100 proteins: structure, functions and pathology. Front Biosci 2002; 7: 135668.
  • 23
    Tsai ST, Jin YT, Tsai WC et al . S100A2, a potential marker for early recurrence in early-stage oral cancer. Oral Oncol 2005; 41: 34957.
  • 24
    Saleem M, Adhami VM, Ahmad N, Gupta S, Mukhtar H. Prognostic significance of metastasis-associated protein S100A4 (Mts1) in prostate cancer progression and chemoprevention regimens in an autochthonous mouse model. Clin Cancer Res 2005; 11: 14753.
  • 25
    Emberley ED, Niu YL, Njue C, Kliewer EV, Murphy LC, Watson PH. Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer. Clin Cancer Res 2003; 9: 262731.
  • 26
    Hermani A, Hess J, Servi BD et al . Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer. Clin Cancer Res 2005; 11: 514652.
  • 27
    Rehman I, Azzouzi AR, Cross SS et al . Dysregulated expression of S100A11 (calgizzarin) in prostate cancer and precursor lesions. Hum Pathol 2004; 35: 138591.
  • 28
    Memon AA, Sorensen BS, Meldgaard P, Fokdal L, Thykjaer T, Nexo E. Down-regulation of S100C is associated with bladder cancer progression and poor survival. Clin Cancer Res 2005; 11: 60611.
  • 29
    Mori M, Shimada H, Gunji Y et al . S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. Oncol Rep 2004; 11: 128793.
  • 30
    Sakaguchi M, Miyazaki M, Inoue Y et al . Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts. J Cell Biol 2000; 149: 1193206.
  • 31
    Sakaguchi M, Miyazaki M, Sonegawa H et al . PKCα mediates TGFβ-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11. J Cell Biol 2004; 164: 97984.
  • 32
    Roberts AB, Wakefield LM. The two faces of transforming growth factor β in carcinogenesis. Proc Natl Acad Sci USA 2003; 100: 86213.
  • 33
    Cintorino M, Tripod SA, Santopietro R et al . Cytokeratin expression patterns as an indicator of tumour progression in oesophageal squamous cell carcinoma. Anticancer Res 2001; 21: 4195201.
  • 34
    Ben-Ze’ev A, Raz A. Relationship between the organization and synthesis of vimentin and the metastatic capability of B16 melanoma cells. Cancer Res 1985; 45: 263241.
  • 35
    Domagala W, Striker G, Szadowska A, Dukowicz A, Harezga B, Osborn M. p53 protein and vimentin in invasive ductal NOS breast carcinoma –relationship with survival and sites of metastases. Eur J Cancer 1994; 30A: 152734.
  • 36
    Gilles C, Polette M, Piette J et al . Vimentin expression in cervical carcinomas: association with invasive and migratory potential. J Pathol 1996; 180: 17580.
  • 37
    Yuan RH, Jeng YM, Chen HL et al . Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma. J Pathol 2006; 209: 54958.
  • 38
    Baldassarre G, Belletti B, Nicoloso MS et al . p27 (Kip1)–stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell 2005; 7: 5163.
  • 39
    Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J. PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 1999; 155: 71115.
  • 40
    Yamazaki T, Hibi K, Takase T et al . PGP9.5 as a marker for invasive colorectal cancer. Clin Cancer Res 2002; 8: 1925.
  • 41
    Mandelker DL, Yamashita K, Tokumaru Y et al . PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. Cancer Res 2005; 65: 49638.
  • 42
    Thor A, Benz C, Moore D et al . Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations. J Natl Cancer Inst 1991; 83: 1708.
  • 43
    Langdon SP, Rabiasz GJ, Hirst GL et al . Expression of the heat shock protein HSP27 in human ovarian cancer. Clin Cancer Res 1995; 1: 16039.
  • 44
    Tetu B, Lacasse B, Bouchard HL, Lagace R, Huot J, Landry J. Prognostic influence of HSP-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohistochemical study. Cancer Res 1992; 52: 23258.
  • 45
    Ungar DR, Hailat N, Strahler JR et al . Hsp27 expression in neuroblastoma: correlation with disease stage. J Natl Cancer Inst 1994; 86: 7804.
  • 46
    Brichory F, Beer D, Naour FL, Giordano T, Hanash S. Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer. Cancer Res 2001; 61: 790812.
  • 47
    Hughes RC. Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta 1999; 1473: 17285.
  • 48
    Gerbitz KD, Summer J, Schumacher I, Arnold H, Kraft A, Mross K. Enolase isoenzymes as tumour markers. J Clin Chem Clin Biochem 1986; 24: 100916.