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Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa
Article first published online: 19 JUL 2007
DOI: 10.1111/j.1349-7006.2007.00548.x
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How to Cite
Iacopetta, B., Grieu, F., Phillips, M., Ruszkiewicz, A., Moore, J., Minamoto, T. and Kawakami, K. (2007), Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. Cancer Science, 98: 1454–1460. doi: 10.1111/j.1349-7006.2007.00548.x
Publication History
- Issue published online: 19 JUL 2007
- Article first published online: 19 JUL 2007
- (Received April 5, 2007/Revised April 30, 2007/2nd Revised May 16, 2007/Accepted May 24, 2007)
References
- 1, . The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415–28.
- 2
- 3DNA methylation in cancer: too much, but also too little. Oncogene 2002; 21: 5400–13.
- 4, , , Chromosomal instability and tumours promoted by DNA hypomethylation. Science 2003; 300: 455.
- 5, , et al . The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res 2005; 11: 8564–9.
- 6. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4: 988–93.
- 7, , et al . CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999; 96: 8681–6.
- 8, , et al . CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002; 122: 1376–87.
- 9, , et al . Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 2002; 51: 797–802.
- 10, , et al . Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 2005; 129: 837–45.
- 11, , et al . CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38: 787–93.
- 12, , et al . APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer. Int J Cancer 2006; 119: 2272–8.
- 13. Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol 2005; 2: 398–405.
- 14, , et al . The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol 2003; 162: 1361–71.
- 15, , et al . Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum Mol Genet 2005; 14: 319–26.
- 16, , et al . Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell 2006; 9: 199–207.
- 17, , et al . Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumours. Oncogene 2006; 25: 2636–45.
- 18, , et al . Hypomethylation and hypermethylation of DNA in Wilms tumours. Oncogene 2002; 21: 6694–702.
- 19, , et al . Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res 2003; 63: 3133–7.
- 20, , et al . The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylene tetrahydrofolate reductase. Clin Cancer Res 2003; 9: 5860–5.
- 21, , et al . Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumours. Cancer Res 2002; 62: 4519–24.
- 22, , et al . Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 2003; 124: 1240–8.
- 23, , et al . Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut 2005; 54: 648–53.
- 24, , et al . Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994; 7: 536–40.
- 25, , et al . Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite unstable colorectal cancer development. Cancer Res 2001; 61: 6991–5.
- 26, , et al . DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. Br J Cancer 2006; 94: 593–8.
- 27, , et al . Analysis of repetitive element DNA methylation by MethyLight. Nucl Acids Res 2005; 33: 6823–36.
- 28, , et al . BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol Cancer 2006; 5: 2.
- 29, , et al . Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer. Oncology 2003; 64: 259–65.
- 30, Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 2003; 63: 6004–7.
- 31, , , Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies. Oncol Rep 2004; 11: 501–4.
- 32, , et al . Initial sequencing and analysis of the human genome. Nature 2001; 409: 860–921.
- 33, , et al . Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent hypermethylation. Cancer Sci 2004; 95: 58–64.Direct Link:
- 34, , et al . Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 1998; 128: 1204–12.
- 35, , et al . Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 2000; 72: 998–1003.
- 36. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev 2004; 13: 511–19.
- 37, , et al . Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet 2007; 16: 547–54.
- 38, , , . Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylene tetrahydrofolate reductase gene. Cancer Epidemiol Biomark Prev 2000; 9: 849–53.
- 39, , et al . A common mutation in the 5, 10-methylene tetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002; 99: 5606–11.
- 40, , et al . Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell 2003; 4: 121–31.

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