• 1
    Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 1977; 50: 48192.
  • 2
    Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980; 77: 741519.
  • 3
    Blattner WA. Human retroviruses: their role in cancer. Proc Assoc Am Physicians 1999; 111: 56372.
  • 4
    Edlich RF, Arnette JA, Williams FM. Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I). J Emerg Med 2000; 18: 10919.
  • 5
    Shimoyama M, Members of the Lymphoma Study Group (1984–87). Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma: a report from Lymphoma Study Group 1984–87. Br J Haematol 1991; 79: 42837.
  • 6
    Iellem A, Mariani M, Lang R et al . Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T cells. J Exp Med 2001; 194: 84753.
  • 7
    Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a signal mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 115164.
  • 8
    Shevach M. Certified professionals: CD4+CD25+ suppressor T cells. J Exp Med 2001; 193: F426.
  • 9
    Viguier M, Lemaitre F, Verola O et al . Foxp3 expressing CD4+CD25high regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol 2004; 173: 144453.
  • 10
    Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 105761.
  • 11
    Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002; 3: 13542.
  • 12
    Takahashi T, Tagami T, Yamazaki S et al . Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 30310.
  • 13
    Sansom DM, Manzotti CN, Zheng Y. What's the difference between CD80 and CD86? Trends Immunol 2003; 24: 31419.
  • 14
    Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 1996; 183: 254150.
  • 15
    Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995; 182: 45965.
  • 16
    Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3: 5417.
  • 17
    Yoshie O, Fujisawa R, Nakayama T et al . Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. Blood 2002; 99: 150511.
  • 18
    Ishida T, Utsunomia Y, Iida S et al . Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res 2003; 9: 362534.
  • 19
    Ishida T, Iida S, Akatsuka Y et al . The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma. Clin Cancer Res 2004; 15: 752939.
  • 20
    Karube K, Ohshima K, Tsuchiya T et al . Expression of Foxp3, a key molecule in CD4+CD25+ regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol 2004; 126: 814.
  • 21
    Matsubara Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells. Leukemia 2005; 19: 4823.
  • 22
    Kohno T, Yamada Y, Akamatsu N et al . Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells. Cancer Sci 2005; 96: 52733.
  • 23
    Chen S, Ishii N, Ine S et al . Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol 2006; 18: 26977.
  • 24
    Walsh PT, Benoit BM, Wysoocka M, Dalton NM, Turka LA, Rook AH. A role for regulatory T cells in cutaneous T-cell lymphoma; induction of a CD4+CD25+Foxp3+ T cell phenotype associated with HTLV-I infection. J Invest Dermatol 2006; 126: 6902.
  • 25
    Shimauchi T, Imai S, Hino R, Tokura Y. Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells. Clin Cancer Res 2005; 11: 242735.
  • 26
    Yano H, Ishida T, Inagaki A et al . Regulatory T-cell function of adult T-cell leukemia/lymphoma cells. Int J Cancer 2007; 120: 20527.
  • 27
    Perkins D, Wang Z, Donovan C et al . Regulation of CTLA-4 expression during T cell activation. J Immunol 1996; 156: 41549.
  • 28
    Yamano Y, Cohen CJ, Takenouchi N et al . Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+CD25+ T cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease. J Exp Med 2004; 199: 136777.
  • 29
    Yamano Y, Takenouchi N, Li HC et al . Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. J Clin Invest 2005; 115: 13618.
  • 30
    Sakaguchi S, Sakaguchi N, Shimizu J et al . Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182: 1832.
  • 31
    Akamine H, Takasu N, Komiya I et al . Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukaemia (ATL) and in HTLV-I carriers. Clin Endocrinol 1996; 45: 4616.
  • 32
    Nishioka K, Sumida T, Hasunuma T. Human T lymphotropic virus type I in arthropathy and autoimmune disorders. Arthritis Rheum 1996; 39: 141018.
  • 33
    Muller S, Boire G, Ossondo M et al . IgG autoantibody response in HTLV-I-infected patients. Clin Immunol Immunopathol 1995; 77: 28290.
  • 34
    Sugita K, Shimauchi T, Tokura Y. Chronic actinic dermatitis associated with adult T-cell leukemia. J Am Acad Dermatol 2005; 52: 3840.
  • 35
    Wong HK, Wilson AJ, Gibson HM et al . Increased expression of CTLA-4 in malignant T cells from patients with mycosis fungoides – cutaneous T-cell lymphoma. J Invest Dermatol 2006; 126: 21219.