Present address: Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan. Email: takaoka@igm.hokudai.ac.jp
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Interferon regulatory factor family of transcription factors and regulation of oncogenesis
Article first published online: 9 JAN 2008
DOI: 10.1111/j.1349-7006.2007.00720.x
© 2008 Japanese Cancer Association
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How to Cite
Takaoka, A., Tamura, T. and Taniguchi, T. (2008), Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Science, 99: 467–478. doi: 10.1111/j.1349-7006.2007.00720.x
Publication History
- Issue published online: 9 JAN 2008
- Article first published online: 9 JAN 2008
- (Received November 15, 2007/Revised November 21, 2007/Accepted November 25, 2007)
- Abstract
- Article
- References
- Cited By
A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)-α/β system. The IRF family has now expanded to nine members, and gene-disruption studies have revealed the critical involvement of these members in multiple facets of host defense systems, such as innate and adaptive immune responses and tumor suppression. In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis. (Cancer Sci 2008; 99: 467–478)