• Open Access

Inflammation and cancer: Role of nuclear factor-kappaB activation

Authors

  • Shin Maeda,

    Corresponding author
    1. Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005;
    2. Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
      To whom correspondence should be addressed. E-mail: shinmaeda2-gi@umin.ac.jp; omata-2im@h.u-tokyo.ac.jp
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  • Masao Omata

    1. Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
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To whom correspondence should be addressed. E-mail: shinmaeda2-gi@umin.ac.jp; omata-2im@h.u-tokyo.ac.jp

Abstract

It has been thought that there is a strong relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in many organs. An in-depth understanding of the mechanism by which inflammation can lead to carcinogenesis may enable the development of drugs targeted at important molecules, providing a powerful tool for preventing cancer development. In this review, we focused on a signal transduction system, the nuclear factor-kappaB (NF-κB) pathway, which is thought to play a role in the process leading from inflammation to carcinogenesis, and may thus serve as a candidate for targeted intervention. (Cancer Sci 2008; 99: 836–842)

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