Brief statements: Defective DNA damage response (DDR) can result in genomic instability (GIN) which is considered to be a central aspect of any carcinogenic process. P53-binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DDR proteins. This study demonstrated a number of nuclear 53BP1 foci in human skin tumorigenesis, suggesting a constitutive activation of DDR in skin cancer cells. The results of this study suggest that GIN has a crucial role in the progression of skin carcinogenesis.
Alteration of p53-binding protein 1 expression during skin carcinogenesis: Association with genomic instability
Article first published online: 1 APR 2008
© 2008 Japanese Cancer Association
Volume 99, Issue 5, pages 946–951, May 2008
How to Cite
Naruke, Y., Nakashima, M., Suzuki, K., Matsuu-Matsuyama, M., Shichijo, K., Kondo, H. and Sekine, I. (2008), Alteration of p53-binding protein 1 expression during skin carcinogenesis: Association with genomic instability. Cancer Science, 99: 946–951. doi: 10.1111/j.1349-7006.2008.00786.x
- Issue published online: 1 APR 2008
- Article first published online: 1 APR 2008
- (Received December 13, 2007/Revised January 21, 2008/Accepted January 23, 2008/Online publication March 13, 2008)
Table S1. Odds ratio (OR) and 95% confidence interval (CI) for the incidence of DNA damage response expression of 53BP1 in both normal epidermis and seborrheic keratosis samples.
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