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Fig. S1. Effect of pigment epithelium-derived factor (PEDF) on human umbilical vein endothelial cells (HUVECs) cell proliferation. Primary HUVECs were treated with PEDF at concentrations indicated for 24 h. The viable cells were quantified by MTT. Data represent absorbance as percentages of respective controls (mean ± SD, n = 3), and values statistically different from the control are indicated (*< 0.05). PEDF inhibits proliferation of HUVECs in a dose-dependent manner.

Fig. S2. Quantitative analysis of cell apoptosis induced by pigment epithelium-derived factor (PEDF). Human umbilical vein endothelial cells (HUVECs) and SO-Rb50 cells were treated with PEDF at 200 nnmol/L for 72 h, respectively. Apoptotic cells were dual-stained with AnnexinV and PI, and quantified by flow cytometry. (a) Apoptosis analysis of HUVECs; (b) apoptosis analysis of SO-Rb50 cells. Values significantly higher than control (**< 0.01) are indicated.

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