These authors are co-first authors.
PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo
Article first published online: 1 SEP 2009
© 2009 The Fourth Military Medical University
Volume 100, Issue 12, pages 2451–2458, December 2009
How to Cite
Li, Y., Niu, Y., Wu, H., Zhang, B., Sun, Y., Huang, H., Li, Q., Fan, L., Liu, L. and Mei, Q. (2009), PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo. Cancer Science, 100: 2451–2458. doi: 10.1111/j.1349-7006.2009.01335.x
- Issue published online: 11 NOV 2009
- Article first published online: 1 SEP 2009
- (Received May 24, 2009/Revised July 12, 2009; August 12, 2009/Accepted August 22, 2009/Online publication October 8, 2009)
Fig. S1. The effects of celecoxib and PC-407 (4-[5-naphthyl-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide) on the mRNA level of cyclooxygenase-2 (COX-2), and the protein level of COX-2, COX-1, Bcl-2, Bax, caspase-3, -8, -9, phospho-GSK-3β, β-catenin, and phospho-β-catenin in colorectal cancer (CRC) cells or azoxymethane/dextran sodium sulfate (AOM/DSS)-treated ICR mice. "Quantity one" of Bio-Rad was used to analyze the results of RT-PCR and Western blotting. SPSS 11.0 (SPSS, Chicago, IL, USA) was employed to deal with the data. *P < 120.05 and **P < 0.01 vs control. (a) Results of RT-PCR; (b) results of Western blotting.
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