et al. A 13-week subchronic toxicity study of madder color in F344 rats. Food Chem Toxicol 2008; 46: 241–52. , ,
et al. One-year chronic toxicity of madder color in F344 rats – induction of preneoplastic/neoplastic lesions in the kidney and liver. Food Chem Toxicol 2008; 46: 3303–10. , ,
et al. Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study. Food Chem Toxicol 2009; 47: 184–91. , ,
et al. A review of acute toxicity and genotoxicity data on natural food additives (in Japanese). Toxicol Forum 1985; 8: 91–105. , ,
Mutagenicity of natural food additives in Salmonella typhimurium. Report no. II (in Japanese). Ann Rep Nagoya City Public Health Res Inst 1984; 30: 53–7. , , .
Mutagenicity of anthraquinone and benzanthrone derivatives in the Salmonella/microsome test: activation of anthraquinone glycosides by enzymic extracts of rat cecal bacteria. Mutat Res 1979; 66: 9–24. , .
Formation of genotoxic metabolites from anthraquinone glycosides, present in Rubia tinctorum L. Mutat Res 1992; 265: 263–72. , , , , .
The mutagenic constituents of Rubia tinctorum. Chem Pharm Bull 1992; 40: 1504–9. , , .
Identification of a mutagenic substance, in Rubia tinctorum L. (madder) root, as lucidin. Mutat Res 1983; 121: 185–90. , .
The genotoxicity of lucidin, a natural component of Rubia tinctorum L. and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol 1988; 4: 225–39. , , , , .
Genotoxicity of naturally occurring hydroxyanthraquinones. Mutat Res 1990; 240: 1–12. , , , , , .
Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis 1998; 19: 2163–8. , , .
et al. Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L. Carcinogenesis 1991; 12: 1265–71. , ,
Mutagenicity of natural anthraquinones from Rubia tinctorum in the Drosophila wing spot test. Planta Med 2001; 67: 127–31. , , .
et al. Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats. Food Chem Toxicol 2009; 47: 752–9. , ,
The mutagenic potential of madder root in dyeing processes in the textile industry. Mutat Res 2006; 605: 22–9. , , , , , .
Medium-term-liver and multiorgan carcinogenesis bioassays for carcinogens and chemopriventive agents. Exp Toxicol Pathol 1996; 48: 113–9. , , , , .
Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents: predictive nature and comparison to lesions induced by genotoxic carcinogens. Mutat Res 1991; 248: 239–60. , .
Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Jpn J Cancer Res 1989; 80: 326–30. , , , , .
et al. Promotion potential of madder color in a medium-term multi-organ carcinogenesis bioassay model in F344 rats. J Food Sci 2008; 73: T26–32. , ,
Rubiadin, a new antioxidant from Rubia cordifolia. Indian J Biochem Biophys 1997; 34: 302–6. , , .
Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 2006; 103: 484–90. , , , .
Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995; 93: 55–71. .
Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Human Pathol 1991; 22: 287–94. , , , , .
et al. Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res 1991; 51: 1564–7. , ,
et al. Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis. Cancer Res 2001; 61: 1874–8. , ,
et al. Tumor formation is correlated with expression of ß-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice. Cancer Sci 2004; 95: 316–20. , ,
et al. Azoxymethane-induced beta-catenin-accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis. Carcinogenesis 2003; 24: 107–11. , ,