• 1
    Huang JZ, Sanger WG, Greiner TC et al. The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile. Blood 2002; 99: 228590.
  • 2
    Iqbal J, Sanger WG, Horsman DE et al. BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. Am J Pathol 2004; 165: 15966.
  • 3
    Summers KE, Goff LK, Wilson AG, Gupta RK, Lister TA, Fitzgibbon J. Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma. J Clin Oncol 2001; 19: 4204.
  • 4
    Yasukawa M, Bando S, Dolken G et al. Low frequency of BCL-2/JH translocation in peripheral blood lymphocytes of healthy Japanese individuals. Blood 2001; 98: 4868.
  • 5
    McDonnell TJ, Korsmeyer SJ. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature 1991; 349: 2546.
  • 6
    Strasser A, Harris AW, Cory S. Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene 1993; 8: 19.
  • 7
    Bakhshi A, Wright JJ, Graninger W et al. Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci U S A 1987; 84: 2396400.
  • 8
    Strasser A, Whittingham S, Vaux DL et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci U S A 1991; 88: 86615.
  • 9
    Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. ‘Green mice’ as a source of ubiquitous green cells. FEBS Lett 1997; 407: 3139.
  • 10
    Moreau T, Bardin F, Imbert J, Chabannon C, Tonnelle C. Restriction of transgene expression to the B-lymphoid progeny of human lentivirally transduced CD34+ cells. Mol Ther 2004; 10: 4556.
  • 11
    Moreau T, Barlogis V, Bardin F et al. Development of an enhanced B-specific lentiviral vector expressing BTK: a tool for gene therapy of XLA. Gene Ther 2008; 15: 94252.
  • 12
    Tsuzuki S, Hong D, Gupta R, Matsuo K, Seto M, Enver T. Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med 2007; 4: e172.
  • 13
    Victoratos P, Lagnel J, Tzima S et al. FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity 2006; 24: 6577.
  • 14
    Jolly CJ, Klix N, Neuberger MS. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res 1997; 25: 19139.
  • 15
    Linette GP, Li Y, Roth K, Korsmeyer SJ. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proc Natl Acad Sci U S A 1996; 93: 954552.
  • 16
    Huang DC, O’Reilly LA, Strasser A, Cory S. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J 1997; 16: 462838.
  • 17
    Janumyan YM, Sansam CG, Chattopadhyay A et al. Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. EMBO J 2003; 22: 545970.
  • 18
    Lin B, Kolluri SK, Lin F et al. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 2004; 116: 52740.
  • 19
    McDonnell TJ, Nunez G, Platt FM et al. Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol Cell Biol 1990; 10: 19017.
  • 20
    Adams JM, Harris AW, Strasser A, Ogilvy S, Cory S. Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector. Oncogene 1999; 18: 526877.
  • 21
    Cinamon G, Zachariah MA, Lam OM, Foss FW Jr., Cyster JG. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immun 2008; 9: 5462.
  • 22
    Feske S. Calcium signalling in lymphocyte activation and disease. Nat Rev 2007; 7: 690702.
  • 23
    Gallo EM, Cante-Barrett K, Crabtree GR. Lymphocyte calcium signaling from membrane to nucleus. Nat Immun 2006; 7: 2532.
  • 24
    Shibasaki F, Kondo E, Akagi T, McKeon F. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature 1997; 386: 72831.
  • 25
    Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005; 5: 25162.
  • 26
    Seto M. Genetic and epigenetic factors involved in B-cell lymphomagenesis. Cancer Sci 2004; 95: 70410.
  • 27
    Baens M, Fevery S, Sagaert X et al. Selective expansion of marginal zone B cells in Eμ-API2-MALT1 mice is linked to enhanced IκB kinase γ polyubiquitination. Cancer Res 2006; 66: 52707.
  • 28
    Smith KG, Light A, O’Reilly LA, Ang SM, Strasser A, Tarlinton D. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J Exp Med 2000; 191: 47584.
  • 29
    Phan TG, Paus D, Chan TD et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med 2006; 203: 241924.
  • 30
    Paus D, Phan TG, Chan TD, Gardam S, Basten A, Brink R. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J Exp Med 2006; 203: 108191.
  • 31
    Roulland S, Navarro JM, Grenot P et al. Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. J Exp Med 2006; 203: 242531.
  • 32
    Ruminy P, Jardin F, Picquenot JM et al. Sμ mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells. Blood 2008; 112: 19519.
  • 33
    Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990; 348: 3313.
  • 34
    Shinto Y, Morimoto M, Katsumata M et al. Moloney murine leukemia virus infection accelerates lymphomagenesis in Eμ-bcl-2 transgenic mice. Oncogene 1995; 11: 172936.
  • 35
    Egle A, Harris AW, Bath ML, O’Reilly L, Cory S. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood 2004; 103: 227683.
  • 36
    Dave SS, Wright G, Tan B et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Eng J Med 2004; 351: 215969.