SEARCH

SEARCH BY CITATION

References

  • 1
    Blumberg B, Sabbagh W Jr, Juguilon H et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 1998; 12: 3195205.
  • 2
    Kliewer SA, Moore JT, Wade L et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 1998; 92: 7382.
  • 3
    Moore L, Parks D, Jones S et al. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 2000; 275: 151227.
  • 4
    Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev 2002; 23: 687702.
  • 5
    Carnahan VE, Redinbo MR. Structure and function of the human nuclear xenobiotic receptor PXR. Curr Drug Metab 2005; 6: 35767.
  • 6
    Bertilsson G, Heidrich J, Svensson K et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A 1998; 95: 1220813.
  • 7
    Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001; 276: 145817.
  • 8
    Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001; 7: 58490.
  • 9
    Guengerich F. Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 1999; 39: 117.
  • 10
    Ambudkar S, Kimchi-Sarfaty C, Sauna Z, Gottesman M. P-glycoprotein: from genomics to mechanism. Oncogene 2003; 22: 746885.
  • 11
    Dotzlaw H, Leygue E, Watson P, Murphy LC. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin Cancer Res 1999; 5: 21037.
  • 12
    Miki Y, Suzuki T, Kitada K et al. Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res 2006; 66: 53542.
  • 13
    Conde I, Lobo M, Zamora J et al. Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. BMC Cancer 2008; 8: 174.
  • 14
    Masuyama H, Hiramatsu Y, Kodama J, Kudo T. Expression and potential roles of pregnane X receptor in endometrial cancer. J Clin Endocrinol Metab 2003; 88: 444654.
  • 15
    Chen Y, Tang Y, Wang MT, Zeng S, Nie D. Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res 2007; 67: 103617.
  • 16
    Gupta D, Venkatesh M, Wang H et al. Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Clin Cancer Res 2008; 14: 533240.
  • 17
    Mensah-Osman EJ, Thomas DG, Tabb MM et al. Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer 2007; 109: 95765.
  • 18
    Masuyama H, Nakatsukasa H, Takamoto N, Hiramatsu Y. Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anti-cancer agents in endometrial cancer cells. Mol Pharmacol 2007; 72: 104553.
  • 19
    Harmsen S, Meijerman I, Beijnen JH, Schellens JH. The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. Cancer Treat Rev 2007; 33: 36980.
  • 20
    Zhou J, Liu M, Zhai Y, Xie W. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol Endocrinol 2008; 22: 86880.
  • 21
    Gong H, Singh SV, Singh SP et al. Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 2006; 20: 27990.
  • 22
    Verma S, Tabb M, Blumberg B. Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. BMC Cancer 2009; 9: 3.
  • 23
    Zhou C, Tabb MM, Nelson EL et al. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J Clin Invest 2006; 116: 22809.
  • 24
    Miki Y, Suzuki T, Tazawa C, Blumberg B, Sasano H. Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol 2005; 231: 7585.
  • 25
    Sugawara A, Yen P, Qi Y, Lechan R, Chin W. Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology 1995; 136: 176674.
  • 26
    Goulding H, Pinder S, Cannon P et al. A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples. Hum Pathol 1995; 26: 2914.
  • 27
    Ikeda G, Isaji S, Chandra B, Watanabe M, Kawarada Y. Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus. Cancer 1999; 86: 1396405.
  • 28
    Altman D, Lyman G. Methodological challenges in the evaluation of prognostic factors in breast cancer. Breast Cancer Res Treat 1998; 52: 289303.
  • 29
    Suzuki T, Nakata T, Miki Y et al. Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Cancer Res 2003; 63: 276270.
  • 30
    Kawana K, Ikuta T, Kobayashi Y, Gotoh O, Takeda K, Kawajiri K. Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Mol Pharmacol 2003; 63: 52431.
  • 31
    Zucchini N, De Sousa G, Bailly-Maitre B et al. Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes. Biochim Biophys Acta 2005; 1745: 4858.
  • 32
    Meyer zu Schwabedissen H, Tirona R, Yip C, Ho R, Kim R. Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Cancer Res 2008; 68: 933847.
  • 33
    Zhou C, Tabb MM, Sadatrafiei A, Grun F, Blumberg B. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab Dispos 2004; 32: 107582.
  • 34
    Masuyama H, Suwaki N, Tateishi Y, Nakatsukasa H, Segawa T, Hiramatsu Y. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol Endocrinol 2005; 19: 117080.
  • 35
    Toell A, Kröncke K, Kleinert H, Carlberg C. Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. J Cell Biochem 2002; 85: 7282.
  • 36
    Tanaka H, Kijima H, Tokunaga T et al. Frequent expression of inducible nitric oxide synthase in esophageal squamous cell carcinomas. Int J Oncol 1999; 14: 106973.
  • 37
    Matsumoto M, Furihata M, Kurabayashi A, Araki K, Sasaguri S, Ohtsuki Y. Association between inducible nitric oxide synthase expression and p53 status in human esophageal squamous cell carcinoma. Oncology 2003; 64: 906.
  • 38
    Coggi G, Bosari S, Roncalli M et al. P53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations. Cancer 1997; 79: 42532.
  • 39
    Harris S, Levine A. The p53 pathway: positive and negative feedback loops. Oncogene 2005; 24: 2899908.
  • 40
    Lu Q, Jourd’Heuil F, Jourd’Heuil D. Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest. J Cell Physiol 2007; 212: 82739.
  • 41
    Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 4316.
  • 42
    Conzen S. Minireview: nuclear receptors and breast cancer. Mol Endocrinol 2008; 22: 221528.
  • 43
    Zhang G, Liu X, Farkas A et al. Estrogen receptor beta functions through nongenomic mechanisms in lung cancer cells. Mol Endocrinol 2009; 23: 14656.