• 1
    Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine, 4th edn. New York: Oxford University Press, 2007; 22036.
  • 2
    Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160: 140.
  • 3
    Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 1996; 20: 55366.
  • 4
    Sawa T, Akaike T, Kida K, Fukushima Y, Takagi K, Maeda H. Lipid peroxyl radicals from oxidized oils and heme-iron: implication of a high-fat diet in colon carcinogenesis. Cancer Epidemiol Biomarkers Prev 1998; 7: 100712.
  • 5
    Lee DH, Anderson KE, Folsom AR, Jacobs DR, Jr. Heme iron, zinc and upper digestive tract cancer: the Iowa Women’s Health Study. Int J Cancer 2005; 117: 6437.
  • 6
    Zhou W, Park S, Liu G et al. Dietary iron, zinc, and calcium and the risk of lung cancer. Epidemiology 2005; 16: 7729.
  • 7
    Hann HW, Kim CY, London WT, Blumberg BS. Increased serum ferritin in chronic liver disease: a risk factor for primary hepatocellular carcinoma. Int J Cancer 1989; 43: 3769.
  • 8
    Knekt P, Reunanen A, Takkunen H, Aromaa A, Heliovaara M, Hakulinen T. Body iron stores and risk of cancer. Int J Cancer 1994; 56: 37982.
  • 9
    Selby JV, Friedman GD. Epidemiologic evidence of an association between body iron stores and risk of cancer. Int J Cancer 1988; 41: 67782.
  • 10
    Stevens RG, Graubard BI, Micozzi MS, Neriishi K, Blumberg BS. Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 1994; 56: 3649.
  • 11
    Zacharski LR, Chow BK, Howes PS et al. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst 2008; 100: 9961002.
  • 12
    Cross AJ, Gunter MJ, Wood RJ et al. Iron and colorectal cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study. Int J Cancer 2006; 118: 314752.
  • 13
    Kato I, Dnistrian AM, Schwartz M et al. Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study. Int J Cancer 1999; 80: 6938.
  • 14
    Zacharski LR, Chow BK, Howes PS et al. Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA 2007; 297: 60310.
  • 15
    Loft S, Svoboda P, Kasai H et al. Prospective study of 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion and the risk of lung cancer. Carcinogenesis 2006; 27: 124550.
  • 16
    Cooke MS, Osborne JE, Singh R et al. Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients. Free Radic Biol Med 2007; 43: 132834.
  • 17
    Thanan R, Murata M, Pinlaor S et al. Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis. Cancer Epidemiol Biomarkers Prev 2008; 17: 51824.
  • 18
    Nakano M, Kawanishi Y, Kamohara S et al. Oxidative DNA damage (8-hydroxydeoxyguanosine) and body iron status: a study on 2507 healthy people. Free Radic Biol Med 2003; 35: 82632.
  • 19
    Kasai H, Iwamoto-Tanaka N, Miyamoto T et al. Life style and urinary 8-hydroxydeoxyguanosine, a marker of oxidative dna damage: effects of exercise, working conditions, meat intake, body mass index, and smoking. Jpn J Cancer Res 2001; 92: 915.
  • 20
    Mizoue T, Tokunaga S, Kasai H, Kawai K, Sato M, Kubo T. Body mass index and oxidative DNA damage: a longitudinal study. Cancer Sci 2007; 98: 12548.
  • 21
    Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radic Res 2007; 41: 3248.
  • 22
    Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J. Body iron metabolism and pathophysiology of iron overload. Int J Hematol 2008; 88: 715.
  • 23
    Murakami K, Mizoue T, Sasaki S et al. Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 2008; 24: 1407.
  • 24
    Kasai H, Svoboda P, Yamasaki S, Kawai K. Simultaneous determination of 8-hydroxydeoyguanosine, a marker of oxidative stress, and creatinine, a standardization compound, in urine. Ind Health 2005; 43: 3336.
  • 25
    Sasaki S. Development and evaluation of dietary assessment methods using biomarkers and diet history questionnaires for individuals. (Japanese) In: TanakaH, ed. Research for Evaluation Methods of Nutrition and Dietary Lifestyle Programs Held on Health Japan 21. Summary report. Tokyo: Ministry of Health, Welfare, and Labour, 2004: 1044.
  • 26
    Whitfield JB, Treloar S, Zhu G, Powell LW, Martin NG. Relative importance of female-specific and non-female-specific effects on variation in iron stores between women. Br J Haematol 2003; 120: 8606.
  • 27
    Amagai Y, Ishikawa S, Gotoh T, Kayaba K, Nakamura Y, Kajii E. Age at menopause and mortality in Japan: the Jichi Medical School Cohort Study. J Epidemiol 2006; 16: 1616.
  • 28
    Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 1992; 13: 22417.
  • 29
    Pilger A, Rudiger HW. 8-Hydroxy-2’-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health 2006; 80: 115.
  • 30
    Cook JD, Lipschitz DA, Miles LE, Finch CA. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 1974; 27: 6817.
  • 31
    Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood 2002; 99: 350516.
  • 32
    Reif DW. Ferritin as a source of iron for oxidative damage. Free Radic Biol Med 1992; 12: 41727.
  • 33
    Carbonell T, Rama R. Iron, oxidative stress and early neurological deterioration in ischemic stroke. Curr Med Chem 2007; 14: 85774.
  • 34
    Van Asperen IA, Feskens EJ, Bowles CH, Kromhout D. Body iron stores and mortality due to cancer and ischaemic heart disease: a 17-year follow-up study of elderly men and women. Int J Epidemiol 1995; 24: 66570.
  • 35
    Hercberg S, Estaquio C, Czernichow S et al. Iron status and risk of cancers in the SU.VI.MAX cohort. J Nutr 2005; 135: 26648.
  • 36
    Siah CW, Ombiga J, Adams LA, Trinder D, Olynyk JK. Normal iron metabolism and the pathophysiology of iron overload disorders. Clin Biochem Rev 2006; 27: 516.
  • 37
    Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003; 101: 335964.
  • 38
    Lee DH, Zacharski LR, Jacobs DR, Jr. Comparison of the serum ferritin and percentage of transferrin saturation as exposure markers of iron-driven oxidative stress-related disease outcomes. Am Heart J 2006; 151: 1247.e1,1247.e7.