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Fig. S1. Cox2CRAdΔE3ADPLuc showed luminescence-based imaging in spontaneously developed distant metastases in a nude mouse. (a) By day 13 after intratumoral treatment with Cox2CRAdΔE3ADPLuc (4 × 109 vp/tumor), one mouse bearing an A549 subcutaneous xenograft developed ascites, and bioluminescent signal was detected from the abdominal area. (b) On day 20 after adenovirus (Ad) treatment, the mouse was sacrificed after acquiring the whole-body luciferase imaging, and the peritoneal cavity was opened. (c) To confirm the origin of the bioluminescent signal in the peritoneal cavity, the organs were isolated and placed on a petri dish and re-imaged ex vivo. The source of bioluminescent signal was from distant tumor metastases in the intestines, stomach, diaphragm, and peritoneum.

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