• Please log in or register to access this feature.
You have free access to this content

Epidemiology of cholangiocarcinoma: An update focusing on risk factors

  1. Hai-Rim Shin1,2,*,
  2. Jin-Kyoung Oh2,
  3. Eric Masuyer1,
  4. Maria-Paula Curado1,
  5. Veronique Bouvard1,
  6. Yue-Yi Fang3,
  7. Surapon Wiangnon4,
  8. Banchob Sripa4,
  9. Sung-Tae Hong5

Article first published online: 4 DEC 2009

DOI: 10.1111/j.1349-7006.2009.01458.x

Issue

Cancer Science

Cancer Science

Volume 101, Issue 3, pages 579–585, March 2010

Additional Information

How to Cite

Shin, H.-R., Oh, J.-K., Masuyer, E., Curado, M.-P., Bouvard, V., Fang, Y.-Y., Wiangnon, S., Sripa, B. and Hong, S.-T. (2010), Epidemiology of cholangiocarcinoma: An update focusing on risk factors. Cancer Science, 101: 579–585. doi: 10.1111/j.1349-7006.2009.01458.x

Author Information

  1. 1

    International Agency for Research on Cancer, Lyon, France

  2. 2

    National Cancer Center, Goyang, Korea

  3. 3

    Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China

  4. 4

    Khon Kaen University, Khon Kaen, Thailand

  5. 5

    Seoul National University, Seoul, Korea

* To whom correspondence should be addressed. E-mail: shinhr@iarc.fr

Publication History

  1. Issue published online: 17 FEB 2010
  2. Article first published online: 4 DEC 2009
  3. (Received September 28, 2009/Revised November 9, 2009/Accepted November 20, 2009/Online publication January 18, 2010)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (640K)

References

  • 1
    Nakeeb A, Pitt HA, Sohn TA et al. Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 1996; 224: 463–73; discussion 73–5.
  • 2
    Esposito I, Schirmacher P. Pathological aspects of cholangiocarcinoma. HPB (Oxford) 2008; 10: 83–6.
  • 3
    Parkin DM, Ohshima H, Srivatanakul P, Vatanasapt V. Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention. Cancer Epidemiol Biomarkers Prev 1993; 2: 537–44.
  • 4
    Olnes MJ, Erlich R. A review and update on cholangiocarcinoma. Oncology 2004; 66: 167–79.
  • 5
    Lazaridis KN, Gores GJ. Cholangiocarcinoma. Gastroenterology 2005; 128: 1655–67.
  • 6
    Blechacz BR, Gores GJ. Cholangiocarcinoma. Clin Liver Dis 2008; 12: 131–50, ix.
  • 7
    Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008; 48: 308–21.
  • 8
    Khan SA, Toledano MB, Taylor-Robinson SD. Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford) 2008; 10: 77–82.
  • 9
    Yachimski P, Pratt DS. Cholangiocarcinoma: natural history, treatment, and strategies for surveillance in high-risk patients. J Clin Gastroenterol 2008; 42: 178–90.
  • 10
    DeOliveira ML, Cunningham SC, Cameron JL et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 2007; 245: 755–62.
  • 11
    Primary liver cancer in Japan. Clinicopathologic features and results of surgical treatment. Liver Cancer Study Group of Japan. Ann Surg 1990; 211: 277–87.
  • 12
    Jung MY, Shin HR, Lee CU, Y SS, Lee SW, Park BC. A study of the ratio of hepatocellular carcinoma over cholangiocarcinoma and their risk factors. J Pusan Med Assoc 1993; 29: 29–37.
  • 13
    Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 2001; 33: 1353–7.
  • 14
    Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis 2004; 24: 115–25.
  • 15
    McGlynn KA, Tarone RE, El-Serag HB. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev 2006; 15: 1198–203.
  • 16
    West J, Wood H, Logan RF, Quinn M, Aithal GP. Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971–2001. Br J Cancer 2006; 94: 1751–8.
  • 17
    Kim YI. Liver carcinoma and liver fluke infection. Arzneimittelforschung 1984; 34: 1121–6.
  • 18
    Kurathong S, Lerdverasirikul P, Wongpaitoon V et al. Opisthorchis viverrini infection and cholangiocarcinoma. A prospective, case-controlled study. Gastroenterology 1985; 89: 151–6.
  • 19
    Sriamporn S, Pisani P, Pipitgool V, Suwanrungruang K, Kamsa-ard S, Parkin DM. Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand. Trop Med Int Health 2004; 9: 588–94.
  • 20
    Lim MK, Ju YH, Franceschi S et al. Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea. Am J Trop Med Hyg 2006; 75: 93–6.
  • 21
    Lun ZR, Gasser RB, Lai DH et al. Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect Dis 2005; 5: 31–41.
  • 22
    IARC, ed. Schistosomes, Liver Flukes and Helicobactor pylori. Lyon, France: IARC, 1994.
  • 23
    Bouvard V, Baan R, Straif K et al. A review of human carcinogens – Part B: biological agents. Lancet Oncol 2009; 10: 321–2.
  • 24
    Shin HR, Lee CU, Park HJ et al. Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, Korea. Int J Epidemiol 1996; 25: 933–40.
  • 25
    Honjo S, Srivatanakul P, Sriplung H et al. Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand. Int J Cancer 2005; 117: 854–60.
  • 26
    Choi D, Lim JH, Lee KT et al. Cholangiocarcinoma and Clonorchis sinensis infection: a case-control study in Korea. J Hepatol 2006; 44: 1066–73.
  • 27
    Lee TY, Lee SS, Jung SW et al. Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study. Am J Gastroenterol 2008; 103: 1716–20.
  • 28
    Kaewpitoon N, Kaewpitoon SJ, Pengsaa P, Sripa B. Opisthorchis viverrini: the carcinogenic human liver fluke. World J Gastroenterol 2008; 14: 666–74.
  • 29
    Sripa B, Pairojkul C. Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol 2008; 24: 349–56.
  • 30
    Okuda K, Nakanuma Y, Miyazaki M. Cholangiocarcinoma: recent progress. Part 1: epidemiology and etiology. J Gastroenterol Hepatol 2002; 17: 1049–55.
  • 31
    Okuda K, Nakanuma Y, Miyazaki M. Cholangiocarcinoma: recent progress. Part 2: molecular pathology and treatment. J Gastroenterol Hepatol 2002; 17: 1056–63.
  • 32
    Gores GJ. Cholangiocarcinoma: current concepts and insights. Hepatology 2003; 37: 961–9.
  • 33
    Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD. Cholan-giocarcinoma. Lancet 2005; 366: 1303–14.
  • 34
    Rashid A. Cellular and molecular biology of biliary tract cancers. Surg Oncol Clin N Am 2002; 11: 995–1009.
  • 35
    Tsuda H, Satarug S, Bhudhisawasdi V, Kihana T, Sugimura T, Hirohashi S. Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene. Mol Carcinog 1992; 6: 266–9.
  • 36
    Ohashi K, Tsutsumi M, Nakajima Y et al. High rates of Ki-ras point mutation in both intra- and extra-hepatic cholangiocarcinomas. Jpn J Clin Oncol 1994; 24: 305–10.
  • 37
    Konishi M, Ochiai A, Ojima H et al. A new histological classification for intra-operative histological examination of the ductal resection margin in cholangiocarcinoma. Cancer Sci 2008; 100: 255–260.
  • 38
    WHO. Control of Foodborne Trematode Infections. WHO technical Report Series 849, WHO: Genova, 1995; 1–157.
  • 39
    Wu Z, Guan Y, Zhou Z. [Study of an ancient corpse of the Warring States period unearthed from Tomb No. 1 at Guo-Jia Gang in Jingmen City (a comprehensive study)]. J Tongji Med Univ 1996; 16: 1–5.
  • 40
    Fang Y, Cheng Y, Wu J, AZhang Q, Ruan C. Current pevalence of Clonorchis sinensis infection in endemic areas of China. Chin J Parasitol Parasit Dis 2008; 26: 81–6.
  • 41
    Choi MS, Choi D, Choi MH et al. Correlation between sonographic findings and infection intensity in clonorchiasis. Am J Trop Med Hyg 2005; 73: 1139–44.
  • 42
    Chen ER. Clonorchiasis in Taiwan. Southeast Asian J Trop Med Public Health 1991; 22 (Suppl): 184–5.
  • 43
    Yeh TC, Lin PR, Chen ER, Shaio MF. Current status of human parasitic infections in Taiwan. J Microbiol Immunol Infect 2001; 34: 155–60.
  • 44
    Wang JJ, Chung LY, Lee JD et al. Haplorchis infections in intermediate hosts from a clonorchiasis endemic area in Meinung, Taiwan, Republic of China. J Helminthol 2002; 76: 185–8.
  • 45
    Kim TS, Cho SH, Huh S et al. A nationwide survey on the prevalence of intestinal parasitic infections in the Republic of Korea, 2004. Korean J Parasitol 2009; 47: 37–47.
  • 46
    Choi DW. Clonorchis sinensis: life cycle, intermediate hosts, transmission to man and geographical distribution in Korea. Arzneimittelforschung 1984; 34: 1145–51.
  • 47
    Rim HJ. Clonorchiasis: an update. J Helminthol 2005; 79: 269–81.
  • 48
    Cho SH, Lee KY, Lee BC et al. Prevalence of clonorchiasis in southern endemic areas of Korea in 2006. Korean J Parasitol 2008; 46: 133–7.
  • 49
    De NV, Murrell KD, Cong LD et al. The foodborne termatode zoonoses of Vietnam. Southeast Asian J Trop Med Public Health 2003; 34 (Suppl 1): 12–34.
  • 50
    Verle P, Kongs A, Dr NV et al. Prevalence of intestinal parasitic infection in northern Vietnam. Trop Med Int Health 2003; 8: 961–4.
  • 51
    Trung Dung D, Van De N, Waikagul J et al. Fishborne zoonotic intestinal trematodes, Vietnam. Emerg Infect Dis 2007; 13: 1828–33.
  • 52
    Dang TC, Yajima A, Nguyen VK, Montresor A. Prevalence, intensity and risk factors for clonorchiasis and possible use of questionnaires to detect individuals at risk in northern Vietnam. Trans R Soc Trop Med Hyg 2008; 102: 1263–8.
  • 53
    Nontasut P, Thong TV, Waikagul J et al. Social and behavioral factors associated with Clonorchis infection in one commune located in the Red River Delta of Vietnam. Southeast Asian J Trop Med Public Health 2003; 34: 269–73.
  • 54
    Keiser J, Utzinger J. Emerging foodborne trematodiasis. Emerg Infect Dis 2005; 11: 1507–14.
  • 55
    Harinasuta C, Harinatusa T. Opisthorchis viverrini: life cycle, intermediate hosts, transmission to man and geographical distribution in Thailand. Arzneim-Forsch Drug Res 1984; 34: 1164–7.
  • 56
    Jongsuksuntigul P, Imsomboon T. Opisthorchiasis control in Thailand. Acta Trop 2003; 88: 229–32.
  • 57
    Sithithaworn P, Haswell-Elkins M. Epidemiology of Opisthorchis viverrini. Acta Trop 2003; 88: 187–94.
  • 58
    Rim HJ, Chai JY, Min DY et al. Prevalence of intestinal parasite infections on a national scale among primary schoolchildren in Laos. Parasitol Res 2003; 91: 267–72.
  • 59
    Sayasone S, Odermatt P, Phoumindr N et al. Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR. Trans R Soc Trop Med Hyg 2007; 101: 40–7.
  • 60
    Lee KJ, Bae YT, Kim DH et al. Status of intestinal parasites infection among primary school children in Kampongcham, Cambodia. Korean J Parasitol 2002; 40: 153–5.
  • 61
    Hohmann H, Panzer S, Phimpachan C, Southivong C, Schelp FP. Relationship of intestinal parasites to the environment and to behavioral factors in children in the Bolikhamxay Province of Lao PDR. Southeast Asian J Trop Med Public Health 2001; 32: 4–13.
  • 62
    Fang YY, Wu J, Liu Q et al. Investigaion and analysis on epidemic status clonorchiasis in Guangdong Province, China. J Pathog Biol 2007; 2: 54–6.
  • 63
    Migasena S, Egoramaiphol S, Tungtrongchitr R, Migasena P. Study on serum bile acids in opisthorchiasis in Thailand. J Med Assoc Thai 1983; 66: 464–9.
  • 64
    Changbumrung S, Ratarasarn S, Hongtong K, Migasena P, Vutikes S, Migasena S. Lipid composition of serum lipoprotein in opisthorchiasis. Ann Trop Med Parasitol 1988; 82: 263–9.
  • 65
    Sadun EH. Studies on Opisthorchis viverrini in Thailand. Am J Hyg 1955; 62: 81–115.
  • 66
    De Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM. Biliary tract cancers. N Engl J Med 1999; 341: 1368–78.
  • 67
    Ben-Menachem T. Risk factors for cholangiocarcinoma. Eur J Gastroenterol Hepatol 2007; 19: 615–7.
  • 68
    Kubo S, Kinoshita H, Hirohashi K, Hamba H. Hepatolithiasis associated with cholangiocarcinoma. World J Surg 1995; 19: 637–41.
  • 69
    Chen MF, Jan YY, Jeng LB et al. Intrahepatic cholangiocarcinoma in Taiwan. J Hepatobiliary Pancreat Surg 1999; 6: 136–41.
  • 70
    Su CH, Shyr YM, Lui WY, P’Eng FK. Hepatolithiasis associated with cholangiocarcinoma. Br J Surg 1997; 84: 969–73.
  • 71
    Chen MF. Peripheral cholangiocarcinoma (cholangiocellular carcinoma): clinical features, diagnosis and treatment. J Gastroenterol Hepatol 1999; 14: 1144–9.
  • 72
    Gibson JB. Parasites, Liver Disease and Liver Cancer. Lyon: IARC, 1971.
  • 73
    Kim YI, Yang DH, Chang KR. Relationship between Clonorchis sinensis infestation and cholangiocarcinoma of the liver in Korea. Seoul J Med 1974; 15: 247–53. (in Korean)
  • 74
    Chung CS, Lee SK. An epidemiological study of primary liver carcinomas in Busan area with special reference to clonorchis. Korean J Pathol 1976; 10: 33–46. (in Korean)
  • 75
    Parkin DM, Srivatanakul P, Khlat M et al. Liver cancer in Thailand. I. A case-control study of cholangiocarcinoma. Int J Cancer 1991; 48: 323–8.
  • 76
    Haswell-Elkins MR, Mairiang E, Mairiang P et al. Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int J Cancer 1994; 59: 505–9.
  • 77
    Donato F, Gelatti U, Tagger A et al. Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case-control study in Italy. Cancer Causes Control 2001; 12: 959–64.
  • 78
    Yamamoto S, Kubo S, Hai S et al. Hepatitis C virus infection as a likely etiology of intrahepatic cholangiocarcinoma. Cancer Sci 2004; 95: 592–5.
  • 79
    Shaib YH, El-Serag HB, Davila JA, Morgan R, McGlynn KA. Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study. Gastroenterology 2005; 128: 620–6.
  • 80
    Welzel TM, Graubard BI, El-Serag HB et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study. Clin Gastroenterol Hepatol 2007; 5: 1221–8.
  • 81
    Shaib YH, El-Serag HB, Nooka AK et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study. Am J Gastroenterol 2007; 102: 1016–21.
  • 82
    Zhou YM, Yin ZF, Yang JM et al. Risk factors for intrahepatic cholangiocarcinoma: a case-control study in China. World J Gastroenterol 2008; 14: 632–5.
  • 83
    Hsing AW, Zhang M, Rashid A et al. Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in China. International Journal of Cancer 2008; 122: 1845–53.
  • 84
    Lee CH, Chang CJ, Lin YJ, Yeh CN, Chen MF, Hsieh SY. Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma. Br J Cancer 2009; 100: 1765–70.
  • 85
    El-Serag HB, Engels EA, Landgren O et al. Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: a population-based study of U.S. veterans. Hepatology 2009; 49: 116–23.
View Full Article (HTML) Get PDF (640K)