Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer
Article first published online: 19 NOV 2010
© 2010 Japanese Cancer Association
Volume 102, Issue 1, pages 166–174, January 2011
How to Cite
Kawakami, K., Matsunoki, A., Kaneko, M., Saito, K., Watanabe, G. and Minamoto, T. (2011), Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer. Cancer Science, 102: 166–174. doi: 10.1111/j.1349-7006.2010.01776.x
- Issue published online: 15 DEC 2010
- Article first published online: 19 NOV 2010
- Accepted manuscript online: 18 OCT 2010 11:15AM EST
- (Received August 16, 2010/Revised October 6, 2010/Accepted October 8, 2010/Accepted manuscript online October 18, 2010/Article first published online November 19, 2010)
Fig. S1. Kaplan–Meier survival analysis of patient groups stratified according to LINE-1 methylation.
Fig. S2. Association between LINE-1 methylation and LOH on chromosome 18q in CRC.
Fig. S3. Kaplan–Meier survival analysis of the patients stratified according to the use of post-operative adjuvant chemotherapy.
Table S1. Primer and siRNA sequences used in the present study.
Table S2. Association between the LINE-1 methylation level and clinicopathological features in MSS/CIMP− patients.
Table S3. Patient characteristics according to LINE-1 methylation in the subgroup treated with surgery alone.
Table S4. Patient characteristics in the subgroups analyzed for associations between LINE-1 methylation, prognosis and benefit from adjuvant chemotherapy.
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