Fig. S1. Kaplan–Meier survival analysis of patient groups stratified according to LINE-1 methylation.

Fig. S2. Association between LINE-1 methylation and LOH on chromosome 18q in CRC.

Fig. S3. Kaplan–Meier survival analysis of the patients stratified according to the use of post-operative adjuvant chemotherapy.

Table S1. Primer and siRNA sequences used in the present study.

Table S2. Association between the LINE-1 methylation level and clinicopathological features in MSS/CIMP− patients.

Table S3. Patient characteristics according to LINE-1 methylation in the subgroup treated with surgery alone.

Table S4. Patient characteristics in the subgroups analyzed for associations between LINE-1 methylation, prognosis and benefit from adjuvant chemotherapy.

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