Catalase suppression-mediated H2O2 accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis
Article first published online: 24 FEB 2011
© 2011 Japanese Cancer Association
Volume 102, Issue 4, pages 870–876, April 2011
How to Cite
Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L. and Wang, X. (2011), Catalase suppression-mediated H2O2 accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. Cancer Science, 102: 870–876. doi: 10.1111/j.1349-7006.2011.01874.x
- Issue published online: 18 MAR 2011
- Article first published online: 24 FEB 2011
- Accepted manuscript online: 18 JAN 2011 02:06PM EST
- (Received October 19, 2010/Revised January 6, 2011/Accepted January 11, 2011/Accepted manuscript online January 18, 2011)
Fig. S1. HBEC-2 cells are insensitive to wogonin and TNF-induced cytotoxicity and wogonin-mediated hydrogen peroxide generation.
Fig. S2. H2O2 pretreatment sensitizes HeLa cells and Beas-2B cells to TNF-induced cytotoxicity.
Fig. S3. Wogonin suppresses catalase activity in A549 and SKOV3 cells.
Fig. S4. H2O2 inhibits TNF-induced NF-κB activation in HeLa cells.
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