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Fig. S1. Cyclopamine treatment or Gli1 siRNA transfection did not affect the cell number after 16 h culture.

Fig. S2. Hypoxia increases the invasiveness and Hh pathway activation of PDAC in a Shh-independent manner.

Fig. S3. HIF-1α protein expressed under hypoxic conditions.

Fig. S4. Hypoxia increases MMP9 expression by inducing HIF-1a.

Fig. S5. Silencing of HIF-1α did not affect the transcription of Hh-related genes under hypoxia.

Fig. S6. Silencing of Smo or Gli1 did not affect HIF-1α expression under hypoxic conditions.

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