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Inhibitory effect of soluble platelet-derived growth factor receptor β on intraosseous growth of breast cancer cells in nude mice

  1. Top of page
  2. Inhibitory effect of soluble platelet-derived growth factor receptor β on intraosseous growth of breast cancer cells in nude mice
  3. Overexpression of neurone glial-related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer
  4. Effects of dietary flavonoids, luteolin and quercetin, on the reversal of epithelial–mesenchymal transition in A431 epidermal cancer cells

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Page 1904–10

Breast cancer metastases occur preferentially in bone, and these metastases are usually incurable. Bone tissue is the ideal environment for breast cancer cell migration and colonization due to the bone matrix’s release of factors, including platelet-derived growth factor (PDGF), that contribute to the growth of micrometastatic foci. Members of the PDGF family induce cell migration, proliferation, and transformation by activating PDGF receptors (PDGFR). Previously researched strategies for targeting PDGF/PDGFR-mediated tumor growth have limited potential as they lack specificity and efficacy. Shan and colleagues propose a novel strategy of blocking PDGFRβ signaling by using soluble PDGFRβ as a decoy receptor for PDGF-BB and -DD. The binding of PDGF-BB and -DD to PDGFRβ is critical for the growth of breast cancer cells in bone. The researchers established a bone-seeking TNBCT/Bo cell line from human breast cancer cells, and transfected these cells with mammalian expression vector encoding extracellular lesion of PDGFRβ. Athymic nude mice injected with TNBCT/Bo-PGFRβ showed significantly lower tumor incidence than control mice. The authors suggest that soluble PDGFRβ may be useful for blocking the PDGFRβ-mediated cycle of breast cancer bone metastasis.

Overexpression of neurone glial-related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer

  1. Top of page
  2. Inhibitory effect of soluble platelet-derived growth factor receptor β on intraosseous growth of breast cancer cells in nude mice
  3. Overexpression of neurone glial-related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer
  4. Effects of dietary flavonoids, luteolin and quercetin, on the reversal of epithelial–mesenchymal transition in A431 epidermal cancer cells

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Page 1855–61

Colorectal carcinoma (CRC) is one of the most common human cancers. Despite advances in the understanding of CRC’s pathobiology, the identification of patients at risk for treatment failure and poor prognosis remains limited. Recent research on the role of cell adhesion molecules (CAMs) in cancer invasion and metastasis identified L1-CAM as a marker of poor prognosis in patients with CRC. Chan and colleagues investigated the clinical significance of another member of the L1 family of CAMs, neurone glial-related (Nr)-CAM. Overexpression of Nr-CAM has been found in a number of cancers. The researchers found Nr-CAM expression in all 428 CRC samples analyzed but only in 4% of matched controls. A subset of CRC samples showed greater Nr-CAM expression, which was correlated with the presence of vascular invasion, p53 expression, and nodal and distant metastases. These results suggest that Nr-CAM is an independent biomarker of poor prognosis in advanced CRC.

Effects of dietary flavonoids, luteolin and quercetin, on the reversal of epithelial–mesenchymal transition in A431 epidermal cancer cells

  1. Top of page
  2. Inhibitory effect of soluble platelet-derived growth factor receptor β on intraosseous growth of breast cancer cells in nude mice
  3. Overexpression of neurone glial-related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer
  4. Effects of dietary flavonoids, luteolin and quercetin, on the reversal of epithelial–mesenchymal transition in A431 epidermal cancer cells

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Page 1829–39

Flavonoids, polyphenolic compounds that are part of the human diet, have been shown to have antitumor and differentiating properties. Luteolin (Lu) and quercetin (Qu), which may be the most potent plant flavonoids, show a variety of anticancer effects. Expanding on their previous research into Lu and Qu’s antiproliferative properties, Lin and colleagues now describe their evaluation of Lu and Qu’s effect on tumor progression and invasion. The authors compared tumor progression events in parental A431-P cells and A431-III cells, the latter of which are highly invasive due to their increased ability to spread/migrate. Both Lu and Qu reversed cadherin switching, downregulated epithelial–mesenchymal transition markers, moderated the expunging of cell–cell interactions, and suppressed the invasiveness of A431-III cells. The authors suggest that Lu and Qu show potential as chemopreventive, antineoplastic, or chemotherapeutic agents, particularly through the reversal of epithelial–mesenchymal transition in cancer cells.